Ramanathan V D, Badenoch-Jones P, Turk J L
Immunology. 1979 Aug;37(4):881-8.
The activation of complement by a number of metal compounds, previously found to induce chronic inflammation, was investigated. Results obtained were compared with complement activation by inulin and zymosan. It was shown that complement activation by these metal compounds did not necessarily involve either the classical or the alternative pathways. Some of these compounds were unable to activate complement in the absence of detectable plasminogen. The results obtained indicate a relationship between the ability of these compounds to induce chronic inflammation in the guinea-pig and to activate complement.
对先前发现可诱导慢性炎症的多种金属化合物激活补体的情况进行了研究。将所得结果与菊粉和酵母聚糖激活补体的情况进行了比较。结果表明，这些金属化合物激活补体不一定涉及经典途径或替代途径。其中一些化合物在缺乏可检测到的纤溶酶原时无法激活补体。所得结果表明这些化合物在豚鼠中诱导慢性炎症的能力与激活补体之间存在关联。
