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氚标记去甲肾上腺素：通过电刺激从脑片中释放

Tritiated norepinephrine: release from brain slices by electrical stimulation.

作者信息

Baldessarini R J, Kopin I J

出版信息

Science. 1966 Jun 17;152(3729):1630-1. doi: 10.1126/science.152.3729.1630.

DOI:10.1126/science.152.3729.1630
PMID:4160809
Abstract

Slices of rat brain and heart that had concentrated H(3)-norepinephrine were superfused and electrically stimulated. Stimulation induced a marked release of H(3)-norepinephrine with a threshold and a maximum repsonse. Release also occurred with increased concentrations of potassium, presumably due to neuronal depolarization. Inhibition of electrically induced release occurred with low calcium and with chlorpromazine and pentobarbital.

摘要

对已富集³H-去甲肾上腺素的大鼠脑片和心脏切片进行灌流并给予电刺激。刺激诱导³H-去甲肾上腺素显著释放，存在阈值和最大反应。钾离子浓度升高时也会发生释放，推测是由于神经元去极化所致。低钙、氯丙嗪和戊巴比妥可抑制电诱导的释放。

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Science. 1966 Jun 17;152(3729):1630-1. doi: 10.1126/science.152.3729.1630.
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