细胞毒性T细胞对H-Y的反应：与同基因雄性皮肤移植排斥反应的相关性。
Cytotoxic T-cell responses to H-Y: correlation with the rejection of syngeneic male skin grafts.
作者信息
Hurme M, Chandler P R, Hetherington C M, Simpson E
出版信息
J Exp Med. 1978 Mar 1;147(3):768-75. doi: 10.1084/jem.147.3.768.
Abstract
The ability of female mice to rapidly reject syngenic male skin grafts is largely determined by dominant genes in the IB region of the H-2b halotype, whereas the ability to produce anti-H-Y cytotoxic cells is determined by a dominant gene in the IA region the H-2b halotype, or by complementary genes in the IC region of some other haplotypes. Thus, it seems that H-2-retricted anti-H-Y cytotoxic T cells are not responsible for the rejection of syngeneic male skin grafts.
摘要
雌性小鼠迅速排斥同基因雄性皮肤移植的能力在很大程度上由H-2b单倍型IB区域的显性基因决定，而产生抗H-Y细胞毒性细胞的能力则由H-2b单倍型IA区域的显性基因或其他一些单倍型IC区域的互补基因决定。因此，似乎H-2限制的抗H-Y细胞毒性T细胞并不负责同基因雄性皮肤移植的排斥反应。
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