细胞毒性T细胞对H-Y的反应：Ir基因图谱分析
Cytotoxic T-cell responses to H-Y: mapping of the Ir genes.
作者信息
Hurme M, Hetherington C M, Chandler P R, Simpson E
出版信息
J Exp Med. 1978 Mar 1;147(3):758-67. doi: 10.1084/jem.147.3.758.
Abstract
The secondary cytotoxic responses to the male specific antigen (H-Y) in in mice show H-2 restrictions so that cytotoxic female cells must share K and/or D end antigen with the male target cells. The production of cytotoxic cells is under the control of Ir genes, thus offering the possibility of studying the function of Ir genes in H-2-restricted cytotoxic responses. There are two kinds of Ir genes regulating this response; the dominant gene in the H-2b haplotype and complementary genes in other haplotypes. Now we have been able to map the dominant gene and some of the complementary genes: the dominant genes is in IAb, and in H-2k/H-2d complementation, the Ir genes are in ICk and ICd, and in H-2k/H2s and H-2k/H-2q complementations, at least the H-2k gene is in IC.
摘要
小鼠对雄性特异性抗原（H-Y）的继发性细胞毒性反应表现出H-2限制，因此细胞毒性雌性细胞必须与雄性靶细胞共享K和/或D端抗原。细胞毒性细胞的产生受Ir基因控制，从而为研究Ir基因在H-2限制的细胞毒性反应中的功能提供了可能性。有两种Ir基因调节这种反应；H-2b单倍型中的显性基因和其他单倍型中的互补基因。现在我们已经能够定位显性基因和一些互补基因：显性基因位于IAb中，在H-2k/H-2d互补中，Ir基因位于ICk和ICd中，在H-2k/H2s和H-2k/H-2q互补中，至少H-2k基因位于IC中。
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本文引用的文献
1
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Adv Immunol. 1972;15:215-47. doi: 10.1016/s0065-2776(08)60686-0.
2
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
J Exp Med. 1975 Nov 1;142(5):1108-20. doi: 10.1084/jem.142.5.1108.
3
The effect of allogeneic presensitization on H-Y graft survival and in vitro cell-mediated responses to H-y antigen.同种异体预致敏对H-Y移植物存活及体外细胞介导的对H-Y抗原反应的影响。
J Exp Med. 1976 Sep 1;144(3):810-20. doi: 10.1084/jem.144.3.810.
4
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5
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