c-5，c-8，c-11-二十碳三烯酸对前列腺素生物合成的抑制作用。
Inhibition of prostaglandin biosynthesis by c-5,c-8,c-11-eicosatrienoic acid.
作者信息
van Evert W C, Nugteren D H, van Dorp D A
出版信息
Prostaglandins. 1978 Feb;15(2):267-72. doi: 10.1016/0090-6980(78)90165-x.
The enzyme prostaglandin H leads to E-isomerase (EC 5.3.99.3), which is present in sheep vesicular gland and needs glutathione as cofactor, is inhibited by c-5,c-8,c-11-eicosatrienoic acid, the fatty acid accumulating during essential fatty acid deficiency. The EFA-deficiency syndrome can partly be explained from a prostaglandin deficiency caused by lack of precursors. The present finding indicates that 5,8,11-eicosatrienoic acid could well be an additional factor in modifying the symptoms of EFA-deficiency.
前列腺素H合成酶E-异构酶（EC 5.3.99.3）存在于绵羊精囊腺中，以谷胱甘肽作为辅因子，可被必需脂肪酸缺乏时蓄积的脂肪酸c-5，c-8，c-11-二十碳三烯酸抑制。必需脂肪酸缺乏综合征部分可以从缺乏前体导致的前列腺素缺乏来解释。目前的研究结果表明，5,8,11-二十碳三烯酸很可能是改变必需脂肪酸缺乏症状的另一个因素。
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