Fallon J A, Tall A R, Janis M G, Brauer M J
Acta Haematol. 1978;59(3):163-70. doi: 10.1159/000207758.
The development of granulocytopenia during oxacillin therapy is reported in 2 patients. In both cases the onset of granulocytopenia occurred 24 days after therapy was instituted with similar clinical presentations. The bone marrow aspirates revealed myeloid hyperplasia, left shift and maturation arrest. 24 h after oxacillin was discontinued the granulocyte counts rapidly rose towards normal, with subsequent complete recovery. Although sought for, leukoagglutinins could not be demonstrated in either patient. The occurrence of granulocytopenia in patients receiving natural and semisynthetic penicillins is reviewed and the mechanisms are outlined.
报告了2例在使用苯唑西林治疗期间发生粒细胞减少症的病例。在这两例中，粒细胞减少症均在开始治疗24天后出现，临床表现相似。骨髓穿刺显示髓细胞增生、核左移和成熟停滞。停用苯唑西林24小时后，粒细胞计数迅速上升至正常，并随后完全恢复。尽管进行了查找，但在这两例患者中均未检测到白细胞凝集素。本文对接受天然青霉素和半合成青霉素治疗的患者中粒细胞减少症的发生情况进行了综述，并概述了其机制。
