Brook I
South Med J. 1977 May;70(5):565-6. doi: 10.1097/00007611-197705000-00018.
Two cases of granulocytopenia and leukopenia developing after high-dosage oxacillin therapy given intravenously are described. One patient developed leukopenia and granulocytopenia after 17 days of therapy. The conditions were reversible when oxacillin therapy was discontinued. In the other case, the adverse reaction developed within 48 hours after therapy began and the patient died from heart failure. Leukopenia and granulocytopenia as adverse effects of oxacillin therapy should be kept in mind, especially when high dosages are used.
本文描述了两例静脉注射大剂量苯唑西林治疗后发生粒细胞减少和白细胞减少的病例。一名患者在治疗17天后出现白细胞减少和粒细胞减少。停用苯唑西林治疗后，这些情况是可逆的。在另一例中，不良反应在治疗开始后48小时内出现，患者死于心力衰竭。应牢记苯唑西林治疗的不良反应包括白细胞减少和粒细胞减少，尤其是在使用高剂量时。
