Svehag S E, Chesebro B, Bloth B
Science. 1967 Nov 17;158(3803):933-6. doi: 10.1126/science.158.3803.933.
Electron microscopy of purified Waldenström macroglobulins and normal human and rabbit gammaM immunoglobulins revealed spider-like structures with five legs varying in length and often joining a central ring. Usually only the central more rigid part of this structure (about 150 by 170 angstroms) was clearly visible, but occasionally particles were seen with longer very flexible legs having a total span of about 350 angstroms. Molecules of gammaM antibody retained antibody activity during preparation for electron microscopy. Human and rabbit alpha macroglobulins revealed more rigid symmetric structures (100 by 200 angstroms) which resembled the Russian letter .
对纯化的瓦尔登斯特伦巨球蛋白以及正常人和兔的γM免疫球蛋白进行电子显微镜观察，发现了类似蜘蛛的结构，有五条长短不一的腿，且常常连接到一个中心环上。通常只有该结构中央较硬的部分（约150×170埃）清晰可见，但偶尔也能看到腿更长且非常柔韧、总跨度约为350埃的颗粒。γM抗体分子在制备用于电子显微镜观察的过程中保留了抗体活性。人和兔的α巨球蛋白呈现出更硬的对称结构（100×200埃），类似于俄语字母 。
