Fondu P, Hågå P, Halvorsen S
Br J Haematol. 1978 Jan;38(1):29-36. doi: 10.1111/j.1365-2141.1978.tb07105.x.
The erythropoietin (ESF) content of plasma and urine has been studied in children with protein-energy-malnutrition (PEM) living in the Kivu province at an altitude of 1467--2000 m. On admission, packed cell volume (PCV) was moderately reduced; after 2 months of refeeding PCV had increased but was still lower than in the controls. Plasma ESF was increased on admission and in patients refed for 2 months. The expected positive correlation between serum and urine ESF levels was found after refeeding but not on admission; the last finding could not be explained by the presence of erythropoiesis inhibiting factor(s) in the urine. In spite of the normal 2,3-DPG and P50 previously described in PEM in Kivu, the anaemia associated with this disease is not merely an adaptation to lowered oxygen consumption and there must be some disturbances in the responsiveness of bone marrow to ESF. The high ESF values observed after 2 months of refeeding confirm that the restoration of the red cell volume proceeds slowly.
对生活在海拔1467 - 2000米的基伍省、患有蛋白质-能量营养不良（PEM）的儿童的血浆和尿液中的促红细胞生成素（ESF）含量进行了研究。入院时，红细胞压积（PCV）中度降低；再喂养2个月后，PCV有所增加，但仍低于对照组。入院时以及再喂养2个月的患者血浆ESF均升高。再喂养后发现血清和尿液ESF水平之间存在预期的正相关，但入院时未发现；最后这一发现无法用尿液中存在促红细胞生成抑制因子来解释。尽管此前描述的基伍PEM患者的2,3 - 二磷酸甘油酸（2,3-DPG）和P50正常，但与该疾病相关的贫血不仅仅是对降低的氧消耗的一种适应，骨髓对ESF的反应性肯定存在一些紊乱。再喂养2个月后观察到的高ESF值证实红细胞体积的恢复进展缓慢。
