Holmes G E, Holmes F F
Cancer. 1978 Apr;41(4):1317-22. doi: 10.1002/1097-0142(197804)41:4<1317::aid-cncr2820410416>3.0.co;2-s.
Normal reproduction prosepcts for Hodgkin's disease patients are unknown. This study compares the outcome of 93 pregnancies in 48 patients with 228 pregnancies in 69 sibling controls. No statistically significant differences for spontaneous abortions or abnormal offspring were noted comparing all patients with all controls or 35 irradiated patients with all controls. Pregnancy outcome of 13 patients who received both irradiation and chemotherapy prior to pregnancy appeared to be compromised compared to controls. Wives of male patients in this category were more likely to have spontnaeous abortions than wives of male controls; female patients in this category were significantly more likely to produce abnormal offspring than were female controls (p = 0.047). In this series of patients therapeutic irradiation alone did not appear to jeoparadize posttreatment reproduction in fertile Hodgkin's disease patients but in the smaller group of patients who received both irradiation and chemotherapy the reproduction picture was statistically not as good.
霍奇金病患者的正常生殖前景尚不清楚。本研究比较了48例患者的93次妊娠结果与69名同胞对照者的228次妊娠结果。将所有患者与所有对照者进行比较，或将35名接受过放疗的患者与所有对照者进行比较时，未发现自然流产或异常后代有统计学上的显著差异。与对照组相比，13例在妊娠前接受过放疗和化疗的患者的妊娠结局似乎受到了影响。这类男性患者的妻子比男性对照者的妻子更易发生自然流产；这类女性患者比女性对照者更易生出异常后代（p = 0.047）。在这组患者中，单纯治疗性放疗似乎并未危及可生育的霍奇金病患者治疗后的生殖能力，但在接受过放疗和化疗的较小患者组中，生殖情况在统计学上不太乐观。
