体外脱敏——抗原对腹膜渗出细胞迟发型超敏反应被动转移的特异性抑制。
Desensitization in vitro--the specific inhibition, by antigen, of the passive transfer of delayed hypersensitivity by peritoneal exudate cells.
作者信息
Asherson G L, Stone S H
出版信息
Immunology. 1967 Nov;13(5):469-75.
A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the 24-hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD. The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed hypersensitivity to PPD. Likewise, it was possible to diminish the passive transfer of delayed hypersensitivity to bovine γ-globulin by peritoneal exudate cells, by exposure of the cells to bovine γ-globulin . The recipients were tested immediately after cell transfer. This desensitization was specific, in that the transfer of delayed hypersensitivity to PPD was unaffected. Exposure of cells to hypotonic conditions and antibody to guinea-pig γ-globulin did not prevent the passive transfer of delayed hypersensitivity.
一项初步实验表明，向对牛γ球蛋白具有迟发型超敏反应的豚鼠注射牛γ球蛋白，可降低其对牛γ球蛋白以及（程度较轻的）对结核菌素纯蛋白衍生物（PPD）的24小时皮肤反应。脱敏供体的腹腔渗出细胞传递对牛γ球蛋白迟发型超敏反应的能力降低，但传递对PPD迟发型超敏反应的能力正常。同样，通过将细胞暴露于牛γ球蛋白，可减少腹腔渗出细胞对牛γ球蛋白迟发型超敏反应的被动传递。细胞转移后立即对受体进行检测。这种脱敏具有特异性，因为对PPD迟发型超敏反应的传递不受影响。将细胞暴露于低渗条件以及使用豚鼠γ球蛋白抗体，并不妨碍迟发型超敏反应的被动传递。
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