Pincus T, Haberkern R, Christian C L
J Exp Med. 1968 Apr 1;127(4):819-32. doi: 10.1084/jem.127.4.819.
Three of 16 rabbits injected (intravenously) daily with crystalline bovine serum albumin (BSA) for periods in excess of 10 wk developed chronic glomerulonephritis. In vivo, animals with chronic proteinuria formed variable quantities of soluble complex after injection of antigen while animals without proteinuria exhibited rapid removal of the injected BSA. In vitro studies demonstrated that a major part of the antibodies produced by rabbits with chronic nephritis lacked precipitating properties. Interpretations of these observations were presented in the discussion. It is suggested that, in addition to quantity, quality of antibody plays an important role in the development of chronic serum sickness. Complexes formed with nonprecipitating antibody, which are less rapidly removed from circulation, would have a greater opportunity to deposit in glomeruli and induce inflammation.
16只兔子每天静脉注射结晶牛血清白蛋白(BSA)超过10周,其中3只患上了慢性肾小球肾炎。在体内,患有慢性蛋白尿的动物在注射抗原后形成了数量不等的可溶性复合物,而无蛋白尿的动物则迅速清除了注射的BSA。体外研究表明,患有慢性肾炎的兔子产生的抗体大部分缺乏沉淀特性。讨论中对这些观察结果进行了解释。有人提出,除了抗体的数量外,抗体的质量在慢性血清病的发展中也起着重要作用。与非沉淀抗体形成的复合物从循环中清除的速度较慢,因此有更多机会沉积在肾小球中并引发炎症。