近交系小鼠免疫清除的差异。低亲和力抗体的作用。
Differences in immune elimination in inbred mice. The role of low affinity antibody.
作者信息
Alpers J H, Steward M W, Soothill J F
出版信息
Clin Exp Immunol. 1972 Sep;12(1):121-32.
Abstract
The rate of elimination of soluble protein antigen injected intravenously differs in different inbred strains of mice previously immunized to the antigen. This difference is apparently related to the affinity of the antibody they produce. Animals producing high affinity antibody eliminate antigen more effectively than those producing low affinity antibody. Passive transfer of antibody shows that the difference of antigen elimination is a property of the antibody, rather than the cellular mechanisms involved. The immunopathological significance of these findings is discussed.
摘要
静脉注射可溶性蛋白抗原后，其清除率在先前已对该抗原免疫的不同近交系小鼠中存在差异。这种差异显然与它们产生的抗体亲和力有关。产生高亲和力抗体的动物比产生低亲和力抗体的动物更有效地清除抗原。抗体的被动转移表明，抗原清除的差异是抗体的特性，而非涉及的细胞机制。本文讨论了这些发现的免疫病理学意义。
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