Lieberman R, Mushinski J F, Potter M
Science. 1968 Mar 22;159(3821):1355-7. doi: 10.1126/science.159.3821.1355.
Immunoglobulin A (gammaA) myeloma proteins secreted by plasma-cell tumors of mice are of two types, a common four-chain molecule and a rare two-chain (3.9S) molecule. The close similarity between two-chain gammaA molecules and four-chain gammaA molecules and their polymers is demonstrated in tryptic peptide maps of isolated polypeptide chains and by precipitin reactions with rabbit antiserums to gammaA immzunoglobulins. However, a difference between these two types is distinguishable with homologous antiserums. Homologous antiserums to two-chain gammaA immunoglobulins are specific and do not cross-react with four-chain gammaA immutnoglobulins.
小鼠浆细胞瘤分泌的免疫球蛋白A（γA）骨髓瘤蛋白有两种类型，一种是常见的四链分子，另一种是罕见的双链（3.9S）分子。通过分离多肽链的胰蛋白酶肽图以及与兔抗γA免疫球蛋白抗血清的沉淀反应，证明了双链γA分子与四链γA分子及其聚合物之间的高度相似性。然而，用同源抗血清可以区分这两种类型的差异。双链γA免疫球蛋白的同源抗血清具有特异性，不会与四链γA免疫球蛋白发生交叉反应。
