Foks H, Janowiec M, Manowska W
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):113-8.
6-RNH- and 6-R2NNH-pyrazine-2-carbothioamides 1--3, 5, 6, 9 and 14 were obtained from 2-cyano-6-chloropyrazine. In the in vitro screening the thioamides were active against Myc. tuber. H37Rv at the conc. range of 15.6--250 microgram/cm3. The most active thioamides 1 and 8, however, do not act in experimental tuberculosis in guinea pigs.
6-RNH-和6-R2NNH-吡嗪-2-碳硫酰胺1-3、5、6、9和14是由2-氰基-6-氯吡嗪制得的。在体外筛选中，硫酰胺在浓度范围为15.6-250微克/立方厘米时对结核分枝杆菌H37Rv有活性。然而，活性最强的硫酰胺1和8在豚鼠实验性结核病中并无作用。
