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两性霉素B诱导红细胞膜的结构变化。

Amphotericin B induced structural changes of the erythrocyte membrane.

作者信息

Meyer H W

出版信息

Exp Pathol (Jena). 1979;17(7-8):429-33. doi: 10.1016/s0014-4908(79)80061-7.

DOI:10.1016/s0014-4908(79)80061-7
PMID:41735
Abstract

Incubation of human erythrocytes in isotonic NaCl-sucrose medium with a relative high concentration of amphotericin B results in the occurrence of distinct structures on the membrane faces as visible by freeze-fracturing. Such kind of structures is known to be formed by phase separation of the lipid components (domain formation). The induction of phase separation is considered to be an additional effect of amphotericin B.

摘要

将人红细胞置于含有相对高浓度两性霉素B的等渗氯化钠-蔗糖培养基中孵育,通过冷冻断裂可见膜表面出现明显的结构。已知这种结构是由脂质成分的相分离(结构域形成)形成的。相分离的诱导被认为是两性霉素B的一种附加效应。

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引用本文的文献

1
Echinocyte formation induced by potential changes of human red blood cells.人红细胞电位变化诱导棘红细胞形成。
J Membr Biol. 1982;66(2):79-85. doi: 10.1007/BF01868484.