Hanna M G, Francis M W, Peters L C
Immunology. 1968 Jul;15(1):75-91.
Studies were performed on localization of I-human γ-globulin in spleen lymphatic tissue germinal centres during the primary and secondary immune response as influenced by competitive injections of specific or non-cross-reacting antigens. Isologous mouse 7S serum protein labelled with I was used as the control. The results of these studies support the following conclusions: (1) Antigen retention in germinal centres during the primary immune reaction is a dynamic process. For some antigens there may be opsonins available at the the time of injection which promote initial localization in germinal centres. However, the continued localization of antigen over weeks and months is a function of specific antibody production. (2) For some period of time, germinal centres are specific to the antigen that stimulated their development, and eventually these centres will respond to a different antigen. (3) Antigen persisting in germinal centres is functional in the development of the secondary immune potential.
研究了在初次和二次免疫反应期间，特异性或非交叉反应性抗原的竞争性注射对人源I-γ球蛋白在脾脏淋巴组织生发中心定位的影响。用I标记的同系小鼠7S血清蛋白作为对照。这些研究结果支持以下结论：（1）初次免疫反应期间生发中心的抗原滞留是一个动态过程。对于某些抗原，注射时可能有调理素促进其在生发中心的初始定位。然而，抗原在数周和数月内的持续定位是特异性抗体产生的作用。（2）在一段时间内，生发中心对刺激其发育的抗原具有特异性，最终这些中心会对不同抗原产生反应。（3）生发中心中持续存在的抗原在二次免疫潜能的发展中起作用。
