Halie M R, Thiadens J, Eibergen R, van den Broek A A
Virchows Arch B Cell Pathol. 1978 Mar 2;27(1):39-48.
Spleens with proven though small Hodgkin lesions were examined expecially in relation to the lymphoid tissue normally engaged in the immune response. These Hodgkin foci were always very close to small arteries and surrounded by a lymphocyte corona. Most of the red and white pulp seemed normal, but in some instances abnormal looking large and also multinucleated cells were found scattered through the p.a.l.s. and especially through some follicles. It is considered possible that these isolated cellular abnormalities in the white pulp, when associated with pre-existent Hodgkin foci, represent early Hodgkin lesions. The implications for the dissemination of the disease are discussed. Spread of malignant cells to the spleen is only acceptable within the concept of a homing principle. It is also possible that the lesions arise "de novo". The nature of the observed abnormal cells is not clear. An explanation for the origin of these Sternberg-Reed-like cells from B-lymphocytes would be in accordance with recent data, but another possibility still is that they originate from antigen trapping cells.
对已证实虽小但存在霍奇金病变的脾脏进行了检查，特别关注了通常参与免疫反应的淋巴组织。这些霍奇金病灶总是非常靠近小动脉，并被淋巴细胞冠包围。大部分红髓和白髓看起来正常，但在某些情况下，发现形态异常的大细胞以及多核细胞散在于动脉周围淋巴鞘，尤其是一些滤泡中。有人认为，当这些白髓中孤立的细胞异常与先前存在的霍奇金病灶相关时，可能代表早期霍奇金病变。文中讨论了该病传播的相关问题。恶性细胞扩散至脾脏仅在归巢原则的概念范围内是可接受的。病变也有可能“从头”出现。所观察到的异常细胞的性质尚不清楚。根据最近的数据，这些类施特恩伯格-里德细胞起源于B淋巴细胞是一种解释，但另一种可能性仍然是它们起源于抗原捕获细胞。
