Dahms W T, Molitch M E, Bray G A, Greenway F L, Atkinson R L, Hamilton K
Am J Clin Nutr. 1978 May;31(5):774-8. doi: 10.1093/ajcn/31.5.774.
Mazindol, diethylpropion, and a placebo were compared with behavioral therapy for effectiveness in producing weight reduction in an outpatient obesity clinic. Each method was also compared in cost and harmful side effects. The patients were recruited from the middle and lower socioeconomic groups. Of the 120 patients beginning treatment, only 33 completed the entire 14-week study. There was no statistically significant difference in the weight loss among the treatment groups. The program of behavioral therapy was administered by a dietitian who as experienced in the techniques of behavior modification; the drug treatment groups were seen by physicians. We conclude that behavioral therapy may be the treatment of choice in an outpatient obese population since it requires little physician time, is less expensive, and avoids the side effects of anorectic drugs.
在一家门诊肥胖诊所中，比较了马吲哚、二乙胺苯丙酮和一种安慰剂与行为疗法在减轻体重方面的有效性。还比较了每种方法的成本和有害副作用。患者从社会经济地位中低的群体中招募。在开始治疗的120名患者中，只有33名完成了整个14周的研究。各治疗组之间的体重减轻没有统计学上的显著差异。行为疗法方案由一位在行为矫正技术方面有经验的营养师实施；药物治疗组由医生诊治。我们得出结论，行为疗法可能是门诊肥胖人群的首选治疗方法，因为它所需医生时间少、成本较低，并且避免了食欲抑制药物的副作用。
