乙酰水杨酸对血小板功能的影响。
The effect of acetylsalicyclic acid on platelet function.
作者信息
Evans G, Packham M A, Nishizawa E E, Mustard J F, Murphy E A
出版信息
J Exp Med. 1968 Nov 1;128(5):877-94. doi: 10.1084/jem.128.5.877.
Abstract
Acetylsalicylic acid (ASA, aspirin) and sodium salicylate inhibit platelet aggregation induced by collagen, antigen-antibody complexes, gamma globulin-coated particles or thrombin. These compounds suppress the release of platelet constituents, such as adenosine diphosphate (ADP) and serotonin, induced by such stimuli. Since ASA and sodium salicylate do not inhibit ADP-induced platelet aggregation, it appears that their effect on the action of the other stimuli is due to a decrease in the amount of ADP released. The administration of ASA to rabbits (in doses which inhibited collagen-induced platelet aggregation) impaired hemostasis, prolonged platelet survival, and diminished the amount of deposit formed in an extracorporeal shunt.
摘要
乙酰水杨酸（ASA，阿司匹林）和水杨酸钠可抑制由胶原蛋白、抗原 - 抗体复合物、γ球蛋白包被颗粒或凝血酶诱导的血小板聚集。这些化合物可抑制此类刺激诱导的血小板成分释放，如二磷酸腺苷（ADP）和5-羟色胺。由于ASA和水杨酸钠不抑制ADP诱导的血小板聚集，因此它们对其他刺激作用的影响似乎是由于ADP释放量的减少。给兔子服用ASA（剂量足以抑制胶原蛋白诱导的血小板聚集）会损害止血功能，延长血小板存活时间，并减少体外分流中形成的沉积物量。
相似文献
1
The effect of acetylsalicyclic acid on platelet function.乙酰水杨酸对血小板功能的影响。
J Exp Med. 1968 Nov 1;128(5):877-94. doi: 10.1084/jem.128.5.877.
2
Effect of pyrimido-pyrimidine compounds on platelet function.嘧啶并嘧啶化合物对血小板功能的影响。
J Lab Clin Med. 1971 Jun;77(6):958-74.
3
Alteration of the response of platelets to surface stimuli by pyrazole compounds.吡唑化合物对血小板表面刺激反应的改变。
J Exp Med. 1967 Jul 1;126(1):171-88. doi: 10.1084/jem.126.1.171.
4
Secretory mechanisms. Behaviour of adenine nucleotides during the platelet release reaction induced by adenosine diphosphate and adrenaline.分泌机制。二磷酸腺苷和肾上腺素诱导血小板释放反应过程中腺嘌呤核苷酸的行为。
Biochem J. 1972 Aug;129(1):67-82. doi: 10.1042/bj1290067.
5
The effect of prostaglandin E1 on platelet function in vitro and in vivo.前列腺素E1对体内外血小板功能的影响。
Br J Haematol. 1970 Nov;19(5):559-71. doi: 10.1111/j.1365-2141.1970.tb01639.x.
6
Inhibition by aspirin of release of antiheparin activity from human platelets.阿司匹林对人血小板释放抗肝素活性的抑制作用。
Br Med J. 1969 Aug 16;3(5667):394-6. doi: 10.1136/bmj.3.5667.394.
7
The effect of pyrazole compounds on thrombin-induced platelet aggregation.吡唑化合物对凝血酶诱导的血小板聚集的影响。
Proc Soc Exp Biol Med. 1969 Jan;130(1):72-5. doi: 10.3181/00379727-130-33490.
8
Effet of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3':5'-cyclic monophosphate.前列腺素E1单独及与茶碱或阿司匹林联合使用对胶原诱导的血小板聚集及对包括腺苷3':5'-环磷酸单酯在内的血小板核苷酸的影响。
Biochem J. 1970 Dec;120(4):709-18. doi: 10.1042/bj1200709.
9
Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion.摄入乙酰水杨酸对二磷酸腺苷诱导的继发性聚集及其他血小板功能的抑制作用。
Proc Soc Exp Biol Med. 1968 Feb;127(2):547-51. doi: 10.3181/00379727-127-32737.
10
The influence of salicylate on platelets and whole blood adenine nucleotides.水杨酸盐对血小板及全血腺嘌呤核苷酸的影响。
Br J Pharmacol. 1969 Jul;36(3):437-47. doi: 10.1111/j.1476-5381.1969.tb08000.x.
引用本文的文献
1
A Novel Low-Frequency Electromagnetic Active Inertial Sensor for Drug Detection.一种用于药物检测的新型低频电磁主动惯性传感器。
Sensors (Basel). 2024 May 11;24(10):3059. doi: 10.3390/s24103059.
2
Fifty years with aspirin and platelets.阿司匹林与血小板：五十载探索
Br J Pharmacol. 2023 Jan;180(1):25-43. doi: 10.1111/bph.15966. Epub 2022 Nov 3.
3
New approaches in tail-bleeding assay in mice: improving an important method for designing new anti-thrombotic agents.小鼠尾部出血试验的新方法：改进设计新型抗血栓药物的重要方法
Int J Exp Pathol. 2016 Jun;97(3):285-92. doi: 10.1111/iep.12182. Epub 2016 Jul 5.
4
Aspirin dosing frequency in the primary and secondary prevention of cardiovascular events.心血管事件一级和二级预防中的阿司匹林给药频率。
J Thromb Thrombolysis. 2016 Apr;41(3):493-504. doi: 10.1007/s11239-015-1307-2.
5
Acetylsalicylic Acid in migraine with aura prevention - a retrospective study.阿司匹林用于偏头痛伴先兆预防的回顾性研究
Curr Health Sci J. 2014 Apr-Jun;40(2):126-8. doi: 10.12865/CHSJ.40.02.08. Epub 2014 Mar 29.
6
Should aspirin be used for the primary prevention of cardiovascular disease in the general population?阿司匹林是否应用于普通人群心血管疾病的一级预防？
Med Princ Pract. 2015;24(2):198. doi: 10.1159/000368361. Epub 2014 Nov 1.
7
Impact of aspirin dosing on the effects of P2Y12 inhibition in patients with acute coronary syndromes.阿司匹林剂量对急性冠脉综合征患者P2Y12抑制效果的影响。
J Cardiovasc Transl Res. 2014 Feb;7(1):19-28. doi: 10.1007/s12265-013-9524-6. Epub 2013 Dec 6.
8
Conformational and functional effects induced by D- and L-amino acid epimerization on a single gene encoded peptide from the skin secretion of Hypsiboas punctatus.由 D-和 L-氨基酸差向异构化引起的构象和功能效应对 Hypsiboas punctatus 皮肤分泌物中单个基因编码肽的影响。
PLoS One. 2013;8(4):e59255. doi: 10.1371/journal.pone.0059255. Epub 2013 Apr 2.
9
Historical perspective and future directions in platelet research.血小板研究的历史视角与未来方向。
J Thromb Haemost. 2011 Jul;9 Suppl 1(Suppl 1):374-95. doi: 10.1111/j.1538-7836.2011.04356.x.
10
Historical perspective on ADP-induced platelet activation.ADP诱导血小板活化的历史视角。
Purinergic Signal. 2011 Sep;7(3):283-92. doi: 10.1007/s11302-011-9227-x. Epub 2011 Apr 2.
本文引用的文献
1
STUDY OF PLATELET ADHESIVENESS AND AGGREGATION, WITH LATEX PARTICLES.用乳胶颗粒研究血小板黏附性与聚集性
J Lab Clin Med. 1965 Feb;65:179-201.
2
EFFECT OF ADENOSINE NUCLEOTIDES ON PLATELET AGGREGATION AND CLOTTING TIME.腺苷核苷酸对血小板聚集和凝血时间的影响。
J Lab Clin Med. 1964 Oct;64:548-59.
3
INFLUENCE OF ASPIRIN ON HAEMOSTATIC PARAMETERS.阿司匹林对止血参数的影响。
Ann Rheum Dis. 1964 Nov;23(6):500-4. doi: 10.1136/ard.23.6.500.
4
Factors influencing thrombus formation in vivo.影响体内血栓形成的因素。
Am J Med. 1962 Nov;33:621-47. doi: 10.1016/0002-9343(62)90243-7.
5
Dicumarol therapy. Some effects on platelets and their relationship to clotting tests.双香豆素疗法。对血小板的一些影响及其与凝血试验的关系。
Circ Res. 1960 Nov;8:1187-99. doi: 10.1161/01.res.8.6.1187.
6
Dicumarol therapy and platelet turnover.双香豆素疗法与血小板更新
Circ Res. 1961 Mar;9:402-6. doi: 10.1161/01.res.9.2.402.
7
Determination of the life span of human blood platelets using labelled diisopropylfluorophosphonate.使用标记的二异丙基氟磷酸酯测定人体血小板的寿命
J Clin Invest. 1956 Sep;35(9):964-9. doi: 10.1172/JCI103356.
8
9
[Experimental studies on effects of salicylates on bleeding time].[水杨酸盐对出血时间影响的实验研究]
Med Monatsschr. 1956 Feb;10(2):84-7.
Zotero 插件