阿司匹林对人血小板释放抗肝素活性的抑制作用。
Inhibition by aspirin of release of antiheparin activity from human platelets.
作者信息
Youssef A H, Barkhan P
出版信息
Br Med J. 1969 Aug 16;3(5667):394-6. doi: 10.1136/bmj.3.5667.394.
Abstract
Both in vitro and in vivo, aspirin inhibited the adenosine diphosphate and collagen-induced release of platelet factor 4 (antiheparin factor). The release induced by adrenaline and thrombin was not affected. The in-vivo effect in normal persons lasted for at least three days. Platelet uptake of acetyl-(14)C-aspirin was significantly greater than that of carboxyl-(14)C-aspirin.
摘要
在体外和体内，阿司匹林均能抑制二磷酸腺苷和胶原诱导的血小板因子4（抗肝素因子）的释放。肾上腺素和凝血酶诱导的释放则不受影响。在正常人体内的这种体内效应至少持续三天。乙酰基 -（14）C - 阿司匹林的血小板摄取量显著高于羧基 -（14）C - 阿司匹林。
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