Krasil'nikova O L, Anisova L N, Khokhlov A S
Antibiotiki. 1978 Apr;23(4):308-13.
In complementation analysis of low active streptidine dependent strains of Act. streptomycini, 170 and 145 with mutants having different blocks in biosynthesis of streptomycin it was found that these strains were the donors of some thermostable substances and could reduce the biosynthesis of streptomycin in the mutants having impairements in biosynthesis of streptidine and streptobiosamine, as well as in a number of strains with unknown blocks. It is supposed that the substances produced by mutants 170 and 145 were intermediate products in streptomycin biosynthesis.
在用具有链霉素生物合成中不同阻断的突变体对低活性链霉胍依赖性的链霉菌菌株170和145进行互补分析时,发现这些菌株是某些热稳定物质的供体,并且能够降低在链霉胍和链霉二糖胺生物合成有缺陷的突变体以及一些阻断情况未知的菌株中链霉素的生物合成。据推测,突变体170和145产生的物质是链霉素生物合成中的中间产物。