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良性前列腺增生患者的糖尿病

Diabetes mellitus in patients with benign prostatic hyperplasia.

作者信息

Bourke J B, Griffin J P

出版信息

Br Med J. 1968 Nov 23;4(5629):492-3. doi: 10.1136/bmj.4.5629.492.

DOI:10.1136/bmj.4.5629.492
PMID:4177136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1912667/
Abstract

Of 51 patients submitted to operation for benign prostatic hyperplasia three (5.9%) were knwon, diabetics and two others had undergone surgery for peptic ulcer. Of the remaining patients half (23 out of 46) were found to be diabetic; 40% (20 patients) had a history of previous cardiac infarction or electrocardiograph evidence of myocardial ischaemia.It is suggested that these findings add further support to the hypothesis that benign prostatic hyperplasia is one manifestation of a relative increase of oestrogen secretion with advancing age.

摘要

在接受良性前列腺增生手术的51名患者中,已知有3名(5.9%)患有糖尿病,另外两名曾接受过胃溃疡手术。在其余患者中,一半(46名中的23名)被发现患有糖尿病;40%(20名患者)有既往心肌梗死病史或心电图显示心肌缺血。有人认为,这些发现进一步支持了以下假说,即良性前列腺增生是随着年龄增长雌激素分泌相对增加的一种表现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c1a/1912667/9ad08c92c4b5/brmedj02111-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c1a/1912667/9ad08c92c4b5/brmedj02111-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c1a/1912667/9ad08c92c4b5/brmedj02111-0054-a.jpg

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1
Diabetes mellitus in patients with benign prostatic hyperplasia.良性前列腺增生患者的糖尿病
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High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression.高血糖通过下调 PDK4 表达促进良性前列腺增生。
Sci Rep. 2023 Oct 20;13(1):17910. doi: 10.1038/s41598-023-44954-2.
2
Serum testosterone and prostate-specific antigen levels are major risk factors for prostatic volume increase among benign prostatic hyperplasia patients.血清睾酮和前列腺特异性抗原水平是良性前列腺增生患者前列腺体积增加的主要危险因素。
Asian J Urol. 2021 Jul;8(3):289-297. doi: 10.1016/j.ajur.2020.06.001. Epub 2020 Jun 7.
3
Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions.

本文引用的文献

1
Diabetes Survey in Bedford 1962.1962年贝德福德糖尿病调查
Proc R Soc Med. 1964 Mar;57(3):196-200. doi: 10.1177/003591576405700320.
2
Oestrogen production by Sertoli cells in the etiology of benign senile hypertrophy of the human prostate; testicular lipoid cell ratio and oestrogen-androgen quotient in human male.人前列腺良性老年肥大病因中支持细胞产生雌激素的研究;男性睾丸类脂质细胞比率及雌激素与雄激素商值
Acta Endocrinol (Copenh). 1950;4(1):43-62. doi: 10.1530/acta.0.0040043.
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URINARY EXCRETION OF ESTRONE, ESTRADIOL AND ESTRIOL BY PATIENTS WITH PROSTATIC CANCER AND BENIGN PROSTATIC HYPERTROPHY.
良性前列腺增生:老年男性的一种新的代谢性疾病及其与性功能障碍的相关性。
Int J Endocrinol. 2014;2014:329456. doi: 10.1155/2014/329456. Epub 2014 Feb 13.
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Impact of type 2 diabetes on lower urinary tract symptoms in men: a cohort study.2 型糖尿病对男性下尿路症状的影响:一项队列研究。
BMC Urol. 2013 Feb 20;13:12. doi: 10.1186/1471-2490-13-12.
5
PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.PPARγ 异构体通过差异调控代谢网络来介导小鼠前列腺上皮细胞的分化。
Cell Death Dis. 2012 Aug 9;3(8):e361. doi: 10.1038/cddis.2012.99.
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PPARγ: a molecular link between systemic metabolic disease and benign prostate hyperplasia.过氧化物酶体增殖物激活受体 γ:全身性代谢性疾病与良性前列腺增生之间的分子联系。
Differentiation. 2011 Nov-Dec;82(4-5):220-36. doi: 10.1016/j.diff.2011.05.008. Epub 2011 Jun 8.
7
Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study.强化血糖控制及糖尿病并发症对1型糖尿病男性下尿路症状的影响:糖尿病控制与并发症试验/糖尿病干预与并发症流行病学(DCCT/EDIC)研究
Diabetes Care. 2009 Apr;32(4):664-70. doi: 10.2337/dc07-2375. Epub 2009 Jan 26.
8
Benign prostatic hyperplasia.良性前列腺增生
Br J Gen Pract. 1997 Apr;47(417):235-40.
9
Diabetes associated with prostatic hypertophy and its managemnet in transvesical prostatectomy.糖尿病与前列腺增生及其经膀胱前列腺切除术的治疗
Int Urol Nephrol. 1974;6(2):91-100. doi: 10.1007/BF02082002.
10
Benign prostatic enlargement.良性前列腺增生
Br Med J. 1971 Jan 2;1(5739):31-5. doi: 10.1136/bmj.1.5739.31.
前列腺癌和良性前列腺增生患者雌酮、雌二醇和雌三醇的尿排泄情况
J Urol. 1965 Feb;93:287-95. doi: 10.1016/S0022-5347(17)63760-1.
4
Prevalence of glycosuria and diabetes mellitus. A comprehensive survey in an urban community.糖尿和糖尿病的患病率。一项城市社区的综合调查。
Br Med J. 1962 Jun 2;1(5291):1503-7. doi: 10.1136/bmj.1.5291.1503.
5
What makes the prostate grow.是什么导致前列腺增生?
J Urol. 1953 Sep;70(3):477-88. doi: 10.1016/S0022-5347(17)67935-7.
6
Reduced glucose tolerance in elderly human subjects.老年人体葡萄糖耐量降低。
Diabetes. 1965 Sep;14(9):579-83. doi: 10.2337/diab.14.9.579.
7
Hypertension, diabetes mellitus, and blood groups in benign prostatic hypertrophy.良性前列腺增生症中的高血压、糖尿病与血型
Br J Urol. 1966 Feb;38(1):18-23. doi: 10.1111/j.1464-410x.1966.tb09675.x.