Dudok de Wit C, Borst-Eilers E, Weerdt C M, Kloosterman G J
Br Med J. 1968 Nov 23;4(5629):477-9. doi: 10.1136/bmj.4.5629.477.
A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 mug) in preventing rhesus immunization.In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.
进行了一项对照临床试验,以测试相对低剂量的抗-D免疫球蛋白(250微克)预防恒河猴免疫的有效性。在对照组中,329名女性中有17名(5%)产生了恒河猴抗体,而在治疗组中,333名女性中只有3名(0.9%)出现了主动免疫,这三名女性均有异常大量的经胎盘出血。