布鲁氏菌19号菌株疫苗接种对试管凝集试验效价的影响：一项病例对照研究。
The effects of Brucella strain 19 vaccination on titers in the tube agglutination test: a case control study.
作者信息
Martin S W, Hudson M R
出版信息
Can J Comp Med. 1978 Jan;42(1):35-42.
The degree of agglutination in the tube agglutination test of the sera of 373 "reactor" cattle was compared to that of 800 "non-reactor" cattle from multiple reactor herds in southwestern Ontario. Vaccinated cattle had lower titers than did nonvaccinated cattle. Thus, vaccinated cattle were less likely to be classified as positive than nonvaccinated cattle irrespective of the method of interpreting the results of the tube test. When the full allowance for vaccination was used, vaccinated cattle were less likely to be classified as suspicious than nonvaccinated cattle. The extent of herd vaccination did not appear to markedly influence the effects of vaccination or the prevalence of reactors. Thus, it appeared that vaccination with strain 19 produced a small protective effect (inferred from the lower titers in vaccinated animals), but that the magnitude of this effect was markedly dependent on the appropriateness of the vaccine allowance for classifying cattle. Further work is needed on this aspect of vaccination with strain 19.
将安大略省西南部多个反应牛群中373头“反应牛”血清的试管凝集试验凝集程度与800头“非反应牛”的进行了比较。接种疫苗的牛比未接种疫苗的牛滴度更低。因此，无论采用何种方法解读试管试验结果，接种疫苗的牛比未接种疫苗的牛被判定为阳性的可能性更小。当使用全部疫苗接种考量因素时，接种疫苗的牛比未接种疫苗的牛被判定为可疑的可能性更小。牛群的疫苗接种程度似乎并未显著影响疫苗接种效果或反应牛的流行率。因此，似乎19号菌株疫苗接种产生了较小的保护作用（从接种动物较低的滴度推断），但这种作用的大小明显取决于用于牛分类的疫苗考量因素是否恰当。关于19号菌株疫苗接种的这一方面还需要进一步研究。
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