Meyer R E, Schildkraut J J, Mirin S M, Orsulak P J, Randall M, McDougle M, Platz P A, Grab E, Babor T
Psychopharmacology (Berl). 1978 Apr 11;56(3):327-33. doi: 10.1007/BF00432857.
Indirect evidence has linked opioid reinforcement with changes in noradrenergic metabolism secondary to drug administration. Methodological precedents for biobehavioral correlations in depressive illness have suggested an important association between changes in mood and biogenic amine excretion patterns in the urines of patients during depression and recovery. This paper presents preliminary data on the possible relationship between changes in catecholamine excretion that were observed and the changes in behavior, mood, psychiatric status, and cardiorespiratory physiology secondary to heroin administration and methadone-assisted withdrawal. This study focuses on the urinary excretion of MHPG, since an appreciable fraction of this metabolite is probably derived from norepinephrine originating in the brain. The subjective changes in mood associated with heroin use, the decrease in respiratory rate, and the behavioral and mental status effects associated with opiate intoxication were observed only in the individuals whose MHPG excretion increased during the period of opiate administration.
间接证据表明，阿片类药物的强化作用与给药后去甲肾上腺素能代谢的变化有关。抑郁症生物行为相关性的方法学先例表明，在抑郁和康复期间，患者尿液中的情绪变化与生物胺排泄模式之间存在重要关联。本文呈现了关于观察到的儿茶酚胺排泄变化与海洛因给药及美沙酮辅助戒断继发的行为、情绪、精神状态和心肺生理学变化之间可能关系的初步数据。本研究聚焦于3-甲氧基-4-羟基苯乙二醇（MHPG）的尿排泄，因为这种代谢物的相当一部分可能源自大脑中的去甲肾上腺素。仅在阿片类药物给药期间MHPG排泄增加的个体中观察到了与使用海洛因相关的情绪主观变化、呼吸频率降低以及与阿片类药物中毒相关的行为和精神状态影响。
