肝外胆管梗阻时的血清γ-谷氨酰转移酶同工酶
Serum gamma-glutamyltransferase isoenzymes in extrahepatic biliary obstruction.
作者信息
Wenham P R, Price C P, Sammons H G
出版信息
J Clin Pathol. 1979 Sep;32(9):902-6. doi: 10.1136/jcp.32.9.902.
Abstract
The gamma-glutamyltransferase isoenzymes in the sera of patients with extrahepatic biliary obstruction have been studied, using electrophoretic, gel filtration, and ultracentrifugation techniques, and compared with those present in normal sera. Five isoenzymes were shown to exist in patients' sera, three of which were not demonstrated in normal sera. The observations are discussed in relation to the influence of biliary regurgitation and the possible solubilisation of membrane-bound enzymes. The results are compared with those of previous studies on alkaline phosphatase.
摘要
采用电泳、凝胶过滤和超速离心技术，对肝外胆管梗阻患者血清中的γ-谷氨酰转移酶同工酶进行了研究，并与正常血清中的同工酶进行了比较。结果表明，患者血清中存在五种同工酶，其中三种在正常血清中未被检测到。结合胆汁反流的影响以及膜结合酶可能的溶解情况对这些观察结果进行了讨论。并将结果与先前关于碱性磷酸酶的研究结果进行了比较。
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引用本文的文献
1
Gel-filtration of serum gamma-glutamyl-transpeptidase with HPLC in hepatobiliary diseases and its significance.高效液相色谱法对肝胆疾病患者血清γ-谷氨酰转肽酶进行凝胶过滤及其意义
Gastroenterol Jpn. 1988 Aug;23(4):435-41. doi: 10.1007/BF02779213.
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