肝脏疾病中血清碱性磷酸酶的性质。
The nature of the serum alkaline phosphatases in liver diseases.
作者信息
Price C P, Sammons H G
出版信息
J Clin Pathol. 1974 May;27(5):392-8. doi: 10.1136/jcp.27.5.392.
Abstract
The two main alkaline phosphatase isoenzymes in serum from patients with extrahepatic biliary obstruction have been purified. Properties of these isoenzymes, such as electrophoretic mobility, separation on gel filtration, ultracentrifugation characteristics, Michaelis constants, and sensitivity to neuraminidase have been studied and compared with the isoenzymes of liver and bile. The results show that there is an abnormal isoenzyme in the serum from these patients and that this isoenzyme is similar but not identical with the main bile isoenzyme. It is suggested that it may be associated with a lipoprotein carrier.
摘要
肝外胆管梗阻患者血清中的两种主要碱性磷酸酶同工酶已被纯化。对这些同工酶的性质，如电泳迁移率、凝胶过滤分离、超速离心特性、米氏常数以及对神经氨酸酶的敏感性进行了研究，并与肝脏和胆汁的同工酶进行了比较。结果表明，这些患者血清中存在一种异常同工酶，且该同工酶与主要胆汁同工酶相似但并不相同。有人提出，它可能与一种脂蛋白载体有关。
相似文献
1
The nature of the serum alkaline phosphatases in liver diseases.肝脏疾病中血清碱性磷酸酶的性质。
J Clin Pathol. 1974 May;27(5):392-8. doi: 10.1136/jcp.27.5.392.
2
Purification of an alkaline phosphatase-lipoprotein-X complex.
Clin Chem. 1980 Apr;26(5):604-8.
3
An interpretation of the serum alkaline phosphatase isoenzyme patterns in patients with obstructive liver disease.阻塞性肝病患者血清碱性磷酸酶同工酶谱的解读
J Clin Pathol. 1976 Nov;29(11):976-80. doi: 10.1136/jcp.29.11.976.
4
Mechanism of elevation of serum alkaline phosphatase activity in biliary obstruction: an experimental study.胆道梗阻时血清碱性磷酸酶活性升高的机制：一项实验研究。
Clin Chim Acta. 1980 Oct 23;107(1-2):85-96. doi: 10.1016/0009-8981(80)90417-9.
5
Serum gamma-glutamyltransferase isoenzymes in extrahepatic biliary obstruction.肝外胆管梗阻时的血清γ-谷氨酰转移酶同工酶
J Clin Pathol. 1979 Sep;32(9):902-6. doi: 10.1136/jcp.32.9.902.
6
Solubilization of liver alkaline phosphatase isoenzyme during cholestasis in dogs.犬胆汁淤积期间肝脏碱性磷酸酶同工酶的溶解作用
Am J Vet Res. 1999 Aug;60(8):1010-5.
7
Agarose gel patterns of alkaline phosphatase isoenzymes before and after treatment with neuraminidase.经神经氨酸酶处理前后碱性磷酸酶同工酶的琼脂糖凝胶图谱。
Am J Clin Pathol. 1988 Aug;90(2):181-6. doi: 10.1093/ajcp/90.2.181.
8
[Determination of the isoenzymes of alkaline phosphatase in serum and tissue homogenates with HPLC].[采用高效液相色谱法测定血清和组织匀浆中碱性磷酸酶的同工酶]
Monatsschr Kinderheilkd. 1987 Sep;135(9):632-6.
9
Two macromolecular complexes between alkaline phosphatase and immunoglobulin A in a patient's serum.患者血清中碱性磷酸酶与免疫球蛋白A之间的两种大分子复合物。
Clin Chem. 1983 Oct;29(10):1845-9.
10
The nature of the alkaline phosphatases of bile.胆汁碱性磷酸酶的性质
J Clin Pathol. 1972 Feb;25(2):149-54. doi: 10.1136/jcp.25.2.149.
引用本文的文献
1
Evaluation of analgesic and anti-inflammatory activity of (Spreng) bark.（斯普伦格）树皮的镇痛和抗炎活性评估。
J Tradit Complement Med. 2017 Jan 15;7(4):441-451. doi: 10.1016/j.jtcme.2016.12.009. eCollection 2017 Oct.
2
Evaluation of the anti-arthritic activity of the hydroethanolic leaf extract of Alchornea cordifolia in rats.非洲格木乙醇提取物对大鼠抗关节炎活性的评估。
Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):402-10. doi: 10.4314/ajtcam.v11i2.26. eCollection 2014.
3
Changes in alkaline phosphatase isoenzyme activity in tissues and plasma of Atlantic salmon (Salmo salar) before and during smoltification and gonadal maturation.大西洋鲑（Salmo salar）在变态和性腺成熟前后组织和血浆中碱性磷酸酶同工酶活性的变化。
Fish Physiol Biochem. 1994 Mar;12(6):485-97. doi: 10.1007/BF00004451.
4
Redistribution and fate of colchicine-induced alkaline phosphatase in rat hepatocytes: possible formation of autophagosomes whose membrane is derived from excess plasma membrane.秋水仙碱诱导的碱性磷酸酶在大鼠肝细胞中的再分布及命运：可能形成自噬体，其膜来源于多余的质膜。
Histochem Cell Biol. 1995 Oct;104(4):257-65. doi: 10.1007/BF01464321.
5
Alkaline phosphatase isoenzyme activities in rheumatoid arthritis: hepatobiliary enzyme dissociation and relation to disease activity.类风湿关节炎中的碱性磷酸酶同工酶活性：肝胆酶解离及其与疾病活动的关系。
Ann Rheum Dis. 1993 Jul;52(7):511-6. doi: 10.1136/ard.52.7.511.
6
Measurement of biliary alkaline phosphatase by mini-column chromatography and by electrophoresis and its application to the detection of liver metastases in patients with breast cancer.通过微型柱色谱法和电泳法测定胆汁碱性磷酸酶及其在乳腺癌患者肝转移检测中的应用。
J Clin Pathol. 1984 Feb;37(2):212-7. doi: 10.1136/jcp.37.2.212.
7
The preparation of monoclonal antibodies to human bone and liver alkaline phosphatase and their use in immunoaffinity purification and in studying these enzymes when present in serum.抗人骨和肝碱性磷酸酶单克隆抗体的制备及其在免疫亲和纯化以及血清中这些酶检测方面的应用。
Biochem J. 1987 Jun 15;244(3):725-33. doi: 10.1042/bj2440725.
8
Liver-originating isoenzymes of alkaline phosphatase in the serum: a paraneoplastic manifestation of a malignant schwannoma of the sciatic nerve.血清中碱性磷酸酶的肝脏源性同工酶：坐骨神经恶性神经鞘瘤的副肿瘤表现。
J Clin Pathol. 1976 Mar;29(3):237-40. doi: 10.1136/jcp.29.3.237.
9
An interpretation of the serum alkaline phosphatase isoenzyme patterns in patients with obstructive liver disease.阻塞性肝病患者血清碱性磷酸酶同工酶谱的解读
J Clin Pathol. 1976 Nov;29(11):976-80. doi: 10.1136/jcp.29.11.976.
10
Polyacrylamide gel disc electrophoresis of alkaline phosphatase isoenzymes in bone and liver disease.
J Clin Pathol. 1976 Sep;29(9):782-7. doi: 10.1136/jcp.29.9.782.
本文引用的文献
1
Iso-enzymes of alkaline phosphatase in autolysed and butanol-extracted liver preparations.
Nature. 1962 Mar 10;193:981-2. doi: 10.1038/193981a0.
2
Characterization of tissue alkaline phosphatases and their partial purification by starch-gel electrophoresis.组织碱性磷酸酶的特性及其通过淀粉凝胶电泳进行的部分纯化
Biochem J. 1961 Nov;81(2):441-7. doi: 10.1042/bj0810441.
3
Distribution of alkaline phosphatase in serum protein fractions.血清蛋白组分中碱性磷酸酶的分布
J Clin Pathol. 1962 May;15(3):195-9. doi: 10.1136/jcp.15.3.195.
4
ALKALINE PHOSPHATASE ISOENZYMES IN SERUM AND TISSUE.
S Afr Med J. 1965 Jan 16;39:49-53.
5
ISOENZYMES OF SERUM ALKALINE PHOSPHATASE IN HEPATOBILIARY AND SKELETAL DISEASE.
Am J Clin Pathol. 1963 Oct;40:349-56. doi: 10.1093/ajcp/40.4.349.
6
Fractionation of human-serum proteins by gel filtration.通过凝胶过滤法分离人血清蛋白。
Biochim Biophys Acta. 1962 Oct 8;63:402-10. doi: 10.1016/0006-3002(62)90104-x.
7
Iso-enzymes of alkaline phosphatase.碱性磷酸酶的同工酶
Clin Chim Acta. 1962 Mar;7:255-61. doi: 10.1016/0009-8981(62)90018-9.
8
Serum alkaline phosphatase fractions in hepato-biliary and bone diseases.肝胆疾病和骨病中的血清碱性磷酸酶组分
Clin Sci. 1962 Jun;22:425-34.
9
Zone electrophoretic studies of serum alkaline phosphatase.血清碱性磷酸酶的区带电泳研究。
J Clin Invest. 1959 Apr;38(4):630-44. doi: 10.1172/JCI103841.
10
Localization of 5-nucleotidase and non-specific alkaline phosphatase by starch gel electrophoresis.通过淀粉凝胶电泳对5-核苷酸酶和非特异性碱性磷酸酶进行定位
Proc Soc Exp Biol Med. 1959 Jan;100(1):191-3. doi: 10.3181/00379727-100-24568.
Zotero 插件