肝脏疾病中血清碱性磷酸酶的性质。
The nature of the serum alkaline phosphatases in liver diseases.
作者信息
Price C P, Sammons H G
出版信息
J Clin Pathol. 1974 May;27(5):392-8. doi: 10.1136/jcp.27.5.392.
Abstract
The two main alkaline phosphatase isoenzymes in serum from patients with extrahepatic biliary obstruction have been purified. Properties of these isoenzymes, such as electrophoretic mobility, separation on gel filtration, ultracentrifugation characteristics, Michaelis constants, and sensitivity to neuraminidase have been studied and compared with the isoenzymes of liver and bile. The results show that there is an abnormal isoenzyme in the serum from these patients and that this isoenzyme is similar but not identical with the main bile isoenzyme. It is suggested that it may be associated with a lipoprotein carrier.
摘要
肝外胆管梗阻患者血清中的两种主要碱性磷酸酶同工酶已被纯化。对这些同工酶的性质，如电泳迁移率、凝胶过滤分离、超速离心特性、米氏常数以及对神经氨酸酶的敏感性进行了研究，并与肝脏和胆汁的同工酶进行了比较。结果表明，这些患者血清中存在一种异常同工酶，且该同工酶与主要胆汁同工酶相似但并不相同。有人提出，它可能与一种脂蛋白载体有关。
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