小鼠骨髓瘤MPC 11全长免疫球蛋白κ链的序列
Sequence of the full-length immunoglobulin kappa-chain of mouse myeloma MPC 11.
作者信息
Smith G P
出版信息
Biochem J. 1978 May 1;171(2):337-47. doi: 10.1042/bj1710337.
Abstract
MPC 11 mouse myeloma cells synthesize two immunoglobulin kappa light chains, coded by two separate genes. One of these Kappa-chains has no variable region and is degraded intracellularly. The other is a full-length kappa-chain contaning both variable and constant regions: this chain is secreted, both by itself and combined with heavy chains in molecules of immunoglobulin G. This paper reports the amino acid sequence of the myeloma MPC 11 full-length kappa-chain. The chain is unusual in having 12 extra residues at its N-terminus when its sequence is aligned with those of other mouse kappa-chains; no other anomalies were found in its sequence.
摘要
MPC 11小鼠骨髓瘤细胞合成两种免疫球蛋白κ轻链，由两个不同的基因编码。其中一种κ链没有可变区，在细胞内被降解。另一种是包含可变区和恒定区的全长κ链：该链可单独分泌，也可与免疫球蛋白G分子中的重链结合后分泌。本文报道了骨髓瘤MPC 11全长κ链的氨基酸序列。当该链的序列与其他小鼠κ链的序列比对时，其N端有12个额外的残基，这一点不同寻常；在其序列中未发现其他异常。
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本文引用的文献
1
A protein sequenator.蛋白质测序仪。
Eur J Biochem. 1967 Mar;1(1):80-91. doi: 10.1007/978-3-662-25813-2_14.
2
[The complete automatic sequence analysis of peptides with the aid of quadrol].借助乙二胺四乙酸对肽进行全自动序列分析
Hoppe Seylers Z Physiol Chem. 1971 Dec;352(12):1730-2.
3
Quantitative procedures for use with the Edman-Begg sequenator. Partial sequences of two unusual immunoglobulin light chains, Rzf and Sac.用于埃德曼-贝格蛋白质测序仪的定量方法。两种异常免疫球蛋白轻链Rzf和Sac的部分序列。
Biochemistry. 1971 Dec 21;10(26):4912-21. doi: 10.1021/bi00802a013.
4
Mouse immunoglobulin kappa chain MPC 11: extra amino-terminal residues.小鼠免疫球蛋白κ链MPC 11：额外的氨基末端残基
Science. 1973 Sep 7;181(4103):941-3. doi: 10.1126/science.181.4103.941.
5
Mouse immunoglobulin chains. Pattern of sequence variation among kappa chains with limited sequence differences.小鼠免疫球蛋白链。序列差异有限的κ链之间的序列变异模式。
Biochemistry. 1973 Feb;12(4):760-71. doi: 10.1021/bi00728a028.
6
The complete amino acid sequence of a mouse kappa light chain.小鼠κ轻链的完整氨基酸序列。
Biochem J. 1972 Jun;128(2):427-44. doi: 10.1042/bj1280427.
7
A possible precursor of immunoglobulin light chains.免疫球蛋白轻链的一种可能前体。
Nat New Biol. 1972 Sep 27;239(91):117-20. doi: 10.1038/newbio239117a0.
8
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J Mol Biol. 1974 Nov 5;89(3):409-21. doi: 10.1016/0022-2836(74)90472-0.
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J Exp Med. 1970 Mar 1;131(3):515-41. doi: 10.1084/jem.131.3.515.
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Science. 1967 Jan 27;155(3761):465-7. doi: 10.1126/science.155.3761.465.
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