[水杨酸盐对黄斑肥螈近端曲小管电特性的影响]
[Effects of salicylate on the electrical properties of the proximal convoluted tubule of Necturus maculosus].
作者信息
Teulon J, Anagnostopoulos T
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Feb 6;286(5):415-7.
PMID:418902
Abstract
The effects of peritubular salicylate for chloride substitution were studied in the isolated perfused Necturus kidney. This substitution resulted in changes of cell membrane p.d., varying from tubule to tubule; the withdrawal of the test-anion invariably produced a steep and prolonged depolarization. Exposure of the tissue to salicylate brought about, in addition, electrical uncoupling of junctional membranes, which was not related to concomitant changes of membrane p.d.
摘要
在分离灌注的美西螈肾脏中研究了肾小管周围水杨酸盐对氯离子替代的影响。这种替代导致细胞膜电位发生变化，不同肾小管的变化有所不同；去除测试阴离子总是会产生急剧且持久的去极化。此外，将组织暴露于水杨酸盐会导致连接膜发生电去偶联，这与膜电位的伴随变化无关。
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