Read J A, Miller F C
Obstet Gynecol. 1979 Feb;53(2):166-70.
This study utilized internal fetal monitoring and an on-line voltage control oscillator for measurement of uterine activity unit (UAU) determination in patients who received a paracervical block (PCB) with the use of bupivacaine hydrochloride (Marcaine). The total dose of 25 mg (5 cc/side) of 0.25% bupivacaine used for PCB in 32 patients produced no ill effects to the fetus, as reflected by baseline fetal heart rate (FHR), beat-to-beat variablity, or Apgar scores. No adverse maternal effects were noted, and anesthesia was rated good or excellent in 81% of patients. Rate of cervical dilation remained the same or increased in 29 of 32 patients. Quantitative UAUs showed a significant decrease in the third 10-minute interval after block in primiparas, but no significant change in multiparas or in the group taken as a whole. Total UAUs before versus after PCB for either group or taken together were not statistically different. A decreasing trend in UAUs after PCB versus a positive regression line from activity prior to the block was noted.
本研究利用胎儿内部监测和在线电压控制振荡器,对接受盐酸布比卡因(耐乐品)宫颈旁阻滞(PCB)的患者进行子宫活动单位(UAU)测定。32例患者用于PCB的0.25%布比卡因总剂量为25mg(每侧5cc),未对胎儿产生不良影响,这从基线胎儿心率(FHR)、逐搏变异性或阿氏评分可以看出。未观察到对母体的不良影响,81%的患者麻醉评级为良好或优秀。32例患者中有29例宫颈扩张率保持不变或增加。定量UAU显示,初产妇在阻滞后的第三个10分钟间隔内显著下降,但经产妇或整个组无显著变化。两组或合并后的PCB前后总UAU无统计学差异。注意到PCB后UAU呈下降趋势,与阻滞前活动的正回归线相比。