The importance of histologic grade in stage II endometrial carcinoma.

Twenty-six patients with stage II endometrial carcinoma were reviewed. Survival time was found to be influenced most by histology. Fifteen of 19 patients with a favorable histologic grade survived. The combination of stage II disease and unfavorable histologic condition proved to be ominous, as there were no disease-free survivors in this group. Adequate combinations of pelvic irradiation and operation, as well as radiation therapy alone, provided satisfactory local control. Preoperative external irradiation and intracavitary insertion, followed by total abdominal hysterectomy and bilateral salpingo-oophorectomy, are the preferred treatment sequence.