Schafmayer A, Teichmann R K, Rayford P L, Thompson J C
Surgery. 1979 Feb;85(2):191-5.
The effect of intravenous infusion of L-amino acids (FreAmine II) on gastric secretion and on circulating levels of gastrin was studied in five gastric fistula dogs and three dogs with portacaval transposition. Significant increases in gastric acid secretion were found after infusions which delivered 2.0, 4.0, and 8.0 gm/hr of L-amino acids in five gastric fistula dogs. After portacaval transposition, administration of amino acid solutions via the hindleg (through the liver) resulted in a great fall in the acid secretory response. Gastrin levels were significantly elevated after 8.0 gm/hr of amino acids. After 2.0 and 4.0 gm/hr, there was a slight but insignificant increase in serum gastrin levels. Gastrin levels were unchanged after infusion of 8.0 gm/hr of L-amino acids through the liver. We conclude that L-amino acids given intravenously stimulate gastric acid secretion in a dose-dependent manner by a mechanism which does not involve gastrin. At the highest dosage of amino acids, some gastrin was released which might have stimulated acid output further.
在五只胃瘘犬和三只门腔静脉分流犬中研究了静脉输注L-氨基酸（复方氨基酸注射液II）对胃酸分泌和胃泌素循环水平的影响。在五只胃瘘犬中，当以每小时2.0、4.0和8.0克的速度输注L-氨基酸后，发现胃酸分泌显著增加。门腔静脉分流术后，通过后肢（经肝脏）给予氨基酸溶液导致胃酸分泌反应大幅下降。每小时输注8.0克氨基酸后，胃泌素水平显著升高。每小时输注2.0和4.0克后，血清胃泌素水平有轻微但不显著的升高。经肝脏每小时输注8.0克L-氨基酸后，胃泌素水平未发生变化。我们得出结论，静脉给予L-氨基酸通过一种不涉及胃泌素的机制以剂量依赖的方式刺激胃酸分泌。在氨基酸最高剂量时，释放了一些胃泌素，这可能进一步刺激了胃酸分泌。
