Landor J H, Gough A L, Rai V S, Lim M K
Surg Gynecol Obstet. 1980 Feb;150(2):203-7.
In a group of six dogs with Heidenhain pouches, the infusion of a solution of L-amino acids caused identical increases in gastric secretion when given into the jejunum as when administered directly into the portal venous system. Elevations in plasma amino nitrogen were also similar in the two circumstances. In four dogs with Heidenhain pouches and portacaval transposition, a similar infusion caused an identical increase in gastric secretion when given into the jejunum as when given into the peripheral venous system; plasma amino nitrogen levels were almost as high with the jejunal administration as with venous infusion. It is concluded that all, or almost all, of the gastric secretion evoked by amino acids in the canine intestine can be accounted for by the direct effect of absorbed amino acids on parietal cell secretion, with little or no contribution from release of an intestinal hormone.
在一组六只装有海登海因小胃的狗中，将L - 氨基酸溶液注入空肠时引起的胃酸分泌增加与直接注入门静脉系统时相同。在这两种情况下，血浆氨基氮的升高也相似。在四只装有海登海因小胃且进行了门腔静脉分流术的狗中，类似的注入方式，将溶液注入空肠时引起的胃酸分泌增加与注入外周静脉系统时相同；空肠给药时血浆氨基氮水平几乎与静脉注入时一样高。由此得出结论，犬肠道中氨基酸引起的所有或几乎所有胃酸分泌，都可以由吸收的氨基酸对壁细胞分泌的直接作用来解释，肠道激素释放的贡献很小或没有贡献。
