氢化可的松对免疫球蛋白代谢的影响。
The effect of hydrocortisone on immunoglobulin metabolism.
作者信息
Levy A L, Waldmann T A
出版信息
J Clin Invest. 1970 Sep;49(9):1679-84. doi: 10.1172/JCI106385.
Abstract
The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.
摘要
在接受醋酸氢化可的松的正常和低病原体小鼠中，IgG的所有亚类（γ(2)A、γ(2)B和γ(1)）以及IgA和IgM的血清浓度均降低。使用(131)I标记的IgGγ(2)A亚类进行的周转率研究表明，高剂量皮质类固醇会导致显著缩短的生存期（分解代谢率增加），这导致了观察到的低丙种球蛋白血症。这种分解代谢分数的增加并非由于尿液或粪便中的过量损失，而是反映了内源性分解代谢的增加。
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