• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氢化可的松对免疫球蛋白代谢的影响。

The effect of hydrocortisone on immunoglobulin metabolism.

作者信息

Levy A L, Waldmann T A

出版信息

J Clin Invest. 1970 Sep;49(9):1679-84. doi: 10.1172/JCI106385.

DOI:10.1172/JCI106385
PMID:4194767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC322651/
Abstract

The serum concentration of all subclasses of IgG (gamma(2)A, gamma(2)B, and gamma(1)) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using (131)I-labeled gamma(2)A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.

摘要

在接受醋酸氢化可的松的正常和低病原体小鼠中，IgG的所有亚类（γ(2)A、γ(2)B和γ(1)）以及IgA和IgM的血清浓度均降低。使用(131)I标记的IgGγ(2)A亚类进行的周转率研究表明，高剂量皮质类固醇会导致显著缩短的生存期（分解代谢率增加），这导致了观察到的低丙种球蛋白血症。这种分解代谢分数的增加并非由于尿液或粪便中的过量损失，而是反映了内源性分解代谢的增加。

相似文献

1
The effect of hydrocortisone on immunoglobulin metabolism.氢化可的松对免疫球蛋白代谢的影响。
J Clin Invest. 1970 Sep;49(9):1679-84. doi: 10.1172/JCI106385.
2
Hypogammaglobulinemia associated with accelerated catabolism of IgG secondary to its inteaction with an IgG-reactive monoclonal IgM.低丙种球蛋白血症与IgG因与IgG反应性单克隆IgM相互作用而导致的加速分解代谢相关。
J Clin Invest. 1971 Apr;50(4):951-9. doi: 10.1172/JCI106567.
3
Catabolism of the different classes of immunoglobulins in normal and lethally-irradiated mice.正常和致死剂量照射小鼠体内不同类免疫球蛋白的分解代谢
Prog Immunobiol Stand. 1970;4:67-70.
4
Immunoglobulin metabolism in disease.疾病中的免疫球蛋白代谢
Birth Defects Orig Artic Ser. 1975;11(1):87-94.
5
THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES.小鼠的免疫球蛋白。V. 五类免疫球蛋白的代谢（分解代谢）特性
J Exp Med. 1965 Jul 1;122(1):41-58. doi: 10.1084/jem.122.1.41.
6
Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome. A unique disorder of serum protein metabolism.威斯科特-奥尔德里奇综合征中IgG、IgA、IgM和白蛋白的高分解代谢。一种血清蛋白代谢的独特紊乱。
J Clin Invest. 1971 Nov;50(11):2331-8. doi: 10.1172/JCI106731.
7
Metabolism of bovine immunoglobulin. II. Metabolism of bovine IgG in cattle with secondary hypoimmunoglobulinemia.牛免疫球蛋白的代谢。II. 继发性低免疫球蛋白血症牛体内牛IgG的代谢。
Can J Comp Med Vet Sci. 1967 Apr;31(4):106-10.
8
Metabolic properties of IgG subclasses in man.人类IgG亚类的代谢特性
J Clin Invest. 1970 Apr;49(4):673-80. doi: 10.1172/JCI106279.
9
Disorders of immunoglobulin metabolism.免疫球蛋白代谢紊乱
N Engl J Med. 1969 Nov 20;281(21):1170-7. doi: 10.1056/NEJM196911202812107.
10
The metabolism of different immunoglobulin classes in irradiated mice.辐照小鼠体内不同免疫球蛋白类别的代谢
Immunology. 1969 Sep;17(3):345-65.

引用本文的文献

1
Tuftsin-phosphorylcholine (TPC) equally effective to methylprednisolone in ameliorating lupus nephritis in a mice model.Tuftsin-磷酸胆碱（TPC）在改善狼疮肾炎的小鼠模型中与甲泼尼龙同样有效。
Clin Exp Immunol. 2018 Aug;193(2):160-166. doi: 10.1111/cei.13137.
2
Secondary Antibody Deficiency in Glucocorticoid Therapy Clearly Differs from Primary Antibody Deficiency.糖皮质激素治疗中的次级抗体缺陷明显不同于原发性抗体缺陷。
J Clin Immunol. 2016 May;36(4):406-12. doi: 10.1007/s10875-016-0264-7. Epub 2016 Mar 15.
3
Development of orally active inhibitors of protein and cellular fucosylation.开发具有口服活性的蛋白质和细胞岩藻糖化抑制剂。
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5404-9. doi: 10.1073/pnas.1222263110. Epub 2013 Mar 14.
4
Radioimaging of light chain amyloid with a fibril-reactive monoclonal antibody.使用一种与原纤维反应性单克隆抗体对轻链淀粉样蛋白进行放射性成像。
J Nucl Med. 2006 Dec;47(12):2016-24.
5
Corticosteroid treatment increases parasite numbers in murine giardiasis.皮质类固醇治疗会增加小鼠贾第虫病中的寄生虫数量。
Gut. 1981 Jun;22(6):475-80. doi: 10.1136/gut.22.6.475.
6
Metabolism of IgG in type II mixed essential cryoglobulinaemia--autologous cryoprecipitated and normal homologous IgG are incorporated into complexes and metabolized in vivo at similar rates.II型混合性原发性冷球蛋白血症中IgG的代谢——自体冷沉淀IgG和正常同源IgG被纳入复合物并在体内以相似速率代谢。
Clin Exp Immunol. 1983 Feb;51(2):305-16.
7
Hypercatabolism of IgG, IgA, IgM, and albumin in the Wiskott-Aldrich syndrome. A unique disorder of serum protein metabolism.威斯科特-奥尔德里奇综合征中IgG、IgA、IgM和白蛋白的高分解代谢。一种血清蛋白代谢的独特紊乱。
J Clin Invest. 1971 Nov;50(11):2331-8. doi: 10.1172/JCI106731.
8
Effects of corticosteroids on immunity in man. I. Decreased serum IgG concentration caused by 3 or 5 days of high doses of methylprednisolone.皮质类固醇对人体免疫力的影响。I. 高剂量甲基强的松龙连续3天或5天导致血清IgG浓度降低。
J Clin Invest. 1973 Oct;52(10):2629-40. doi: 10.1172/JCI107455.
9
The relationship between L-chain synthesis and gamma-globulin production.轻链合成与γ球蛋白产生之间的关系。
J Clin Invest. 1973 May;52(5):1067-77. doi: 10.1172/JCI107272.
10
Polyvalent immunoglobulins for prophylaxis of bacterial infections in patients following multiple trauma. A randomized, placebo-controlled study.多价免疫球蛋白用于预防多发伤患者的细菌感染。一项随机、安慰剂对照研究。
Intensive Care Med. 1985;11(6):288-94. doi: 10.1007/BF00273538.

本文引用的文献

1
The mechanism of action of 17-hydroxy-11-dehydrocorticosterone (compound E) and of the adrenocorticotropic hormone in experimental hypersensitivity in rabbits.17-羟基-11-脱氢皮质酮（化合物E）与促肾上腺皮质激素在兔实验性超敏反应中的作用机制
J Exp Med. 1951 Aug;94(2):139-70. doi: 10.1084/jem.94.2.139.
2
Failure of cortisone to affect rate of disappearance of antibody protein.可的松未能影响抗体蛋白的消失速率。
Proc Soc Exp Biol Med. 1951 May;77(1):111-4. doi: 10.3181/00379727-77-18695.
3
Alterations in plasma proteins, plasma volume, and volume of packed red cells in patients receiving ACTH or cortisone.接受促肾上腺皮质激素（ACTH）或可的松治疗的患者血浆蛋白、血浆容量和红细胞压积的变化。
J Lab Clin Med. 1951 Mar;37(3):431-43.
4
The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody.可的松和促肾上腺皮质激素对循环抗体浓度的影响。
J Exp Med. 1951 Jan;93(1):37-48. doi: 10.1084/jem.93.1.37.
5
THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES.小鼠的免疫球蛋白。V. 五类免疫球蛋白的代谢（分解代谢）特性
J Exp Med. 1965 Jul 1;122(1):41-58. doi: 10.1084/jem.122.1.41.
6
QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES.抗体琼脂平板中血清免疫球蛋白的定量测定
J Immunol. 1965 Jan;94:84-90.
7
EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM GAMMA-GLOBULIN CONCENTRATION ON GAMMA-GLOBULIN CATABOLISM.血清γ球蛋白浓度对γ球蛋白分解代谢影响中物种差异的证据。
J Exp Med. 1964 Nov 1;120(5):967-86. doi: 10.1084/jem.120.5.967.
8
The catabolism of 131I-labelled homologous gamma-globulin in normal, hyperthyroid and hypothyroid rats.正常、甲状腺功能亢进和甲状腺功能减退大鼠体内131I标记的同源γ球蛋白的分解代谢
J Endocrinol. 1960 Sep;21:83-9. doi: 10.1677/joe.0.0210083.
9
The effects of adrenocortical hormones on albumin metabolism studied with albumin-I 131.用碘-131标记白蛋白研究肾上腺皮质激素对白蛋白代谢的影响。
J Clin Invest. 1958 Sep;37(9):1229-35. doi: 10.1172/JCI103711.
10
The effect of fever and corticotropin on the in vivo degradation of albumin in man as measured with iodinated human serum albumin.用碘化人血清白蛋白测定发热和促肾上腺皮质激素对人体白蛋白体内降解的影响。
Am J Med Sci. 1958 Jul;236(1):65-80. doi: 10.1097/00000441-195807000-00009.