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狂犬病属特异性核糖核蛋白抗原及一种用于弹状病毒分组和分型的检测系统。

Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses.

作者信息

Schneider L G, Dietzschold B, Dierks R E, Matthaeus W, Enzmann P J, Strohmaier K

出版信息

J Virol. 1973 May;11(5):748-55. doi: 10.1128/JVI.11.5.748-755.1973.

DOI:10.1128/JVI.11.5.748-755.1973
PMID:4196634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355172/
Abstract

Cell-associated ribonucleoprotein (RNP) was isolated from BHK-21 cells infected with several strains of rabies and rabies-related viruses. The RNP-antigen from rabies and related viruses induced the formation of complement-fixing, precipitating, and immunofluorescent antibodies, and proved to be the group-specific antigen common to all rabies viruses. Antigens of the envelope which induce virus-neutralizing antibodies are apparently determinative for the serotype of a virus as evidenced by two-way neutralization tests. A combination of these methods seems to be a useful approach to the serological grouping and typing of rhabdoviruses.

摘要

从感染了几种狂犬病及狂犬病相关病毒毒株的BHK - 21细胞中分离出细胞相关核糖核蛋白（RNP）。来自狂犬病及相关病毒的RNP抗原可诱导补体结合抗体、沉淀抗体和免疫荧光抗体的形成，并且被证明是所有狂犬病病毒共有的群特异性抗原。如双向中和试验所示，诱导病毒中和抗体的包膜抗原显然决定了病毒的血清型。这些方法的联合应用似乎是对弹状病毒进行血清学分群和分型的一种有用方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/c1b733c97343/jvirol00257-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/3eea6f2bbbd4/jvirol00257-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/fb135fdcf822/jvirol00257-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/97cf76286b37/jvirol00257-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/c1b733c97343/jvirol00257-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/3eea6f2bbbd4/jvirol00257-0144-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/fb135fdcf822/jvirol00257-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/97cf76286b37/jvirol00257-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da34/355172/c1b733c97343/jvirol00257-0147-a.jpg

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Rabies group-specific ribonucleoprotein antigen and a test system for grouping and typing of rhabdoviruses.狂犬病属特异性核糖核蛋白抗原及一种用于弹状病毒分组和分型的检测系统。
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