重症肌无力研究。活性肌肉抗原的热稳定性和物种特异性。
Studies in myasthenia gravis. Heat stability and species specificity of active muscle antigens.
作者信息
Rule A H, Bartlett Y P, Osserman K E
出版信息
Immunology. 1973 Jun;24(6):1035-40.
Abstract
Both myosin and actomyosin, active antigens related to antibody induction in myasthenia gravis, show different stabilities. With time or increasing heat treatment, myosin rapidly loses antigenic activity. While actomyosin showed lower initial antigenic activity, both with time and various heat treatments it showed greater stability and final activity. Utilization of actomyosin from several animal sources showed antigenic sites were species related. Human, monkey and rabbit actomyosin were good sources of antigen for studies with human myasthenic sera.
摘要
肌球蛋白和肌动球蛋白这两种与重症肌无力抗体诱导相关的活性抗原，表现出不同的稳定性。随着时间推移或热处理强度增加，肌球蛋白会迅速丧失抗原活性。虽然肌动球蛋白最初的抗原活性较低，但随着时间推移和经过各种热处理后，它表现出更高的稳定性和最终活性。利用来自多种动物来源的肌动球蛋白发现，抗原位点与物种有关。人、猴和兔的肌动球蛋白是用于人重症肌无力血清研究的良好抗原来源。
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