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重症肌无力中的肌肉抗体。

Muscle antibodies in myasthenia gravis.

作者信息

Vetters J M

出版信息

Immunology. 1967 Sep;13(3):275-80.

PMID:4861494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409355/
Abstract

The existence of a second type of antibody to the striations of skeletal muscle is confirmed. This antibody, which reacts with the I bands, is found both in subjects with myasthenia gravis and in normal subjects, but is present in higher titres in the former. The relative frequency of the two types of muscle antibody was estimated in a small group of subjects in whom the thymic changes were known; the possible implications of an association between A band antibody and thymic neoplasia are discussed.

摘要

第二种针对骨骼肌条纹的抗体的存在得到了证实。这种与I带发生反应的抗体,在重症肌无力患者和正常受试者中均有发现,但在前一组患者中的滴度更高。在一小群已知胸腺变化的受试者中估计了两种类型肌肉抗体的相对频率;讨论了A带抗体与胸腺肿瘤之间关联的可能意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/d053d46d08f1/immunology00404-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/237d872247d2/immunology00404-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/740a3108be83/immunology00404-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/8cf9a583016d/immunology00404-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/d053d46d08f1/immunology00404-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/237d872247d2/immunology00404-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/740a3108be83/immunology00404-0055-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/8cf9a583016d/immunology00404-0055-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b824/1409355/d053d46d08f1/immunology00404-0056-a.jpg

相似文献

1
Muscle antibodies in myasthenia gravis.重症肌无力中的肌肉抗体。
Immunology. 1967 Sep;13(3):275-80.
2
[Auotoantibodies in myasthenia gravis].[重症肌无力中的自身抗体]
Nord Med. 1971 Jun 10;85(23):713-8.
3
Autoantibodies in myasthenia gravis: demonstration of anti-motor endplate antibody and anti-muscle membrane antibody using membrane immunofluorescence technique.重症肌无力中的自身抗体:运用膜免疫荧光技术证实抗运动终板抗体和抗肌膜抗体
Acta Med Okayama. 1975 Dec;29(6):397-404.
4
[Antibodies to striated muscle in myasthenia gravis, demonstration of specific reactivity of F (ab')2-piece (author's transl)].重症肌无力中横纹肌抗体,F(ab')2片段特异性反应性的证明(作者译)
Z Immunitatsforsch Exp Klin Immunol. 1972 Jun;143(5):477-82.
5
Antibody to human myosin in man.人体内针对人肌球蛋白的抗体。
Trans Am Neurol Assoc. 1969;94:48-53.
6
[Immunological tolerance and myastenia. The role of thymus in growth and differentiation (author's transl)].[免疫耐受与重症肌无力。胸腺在生长和分化中的作用(作者译)]
Riv Patol Nerv Ment. 1974 Aug;95(4):376-88.
7
[Immunopathology of myasthenia gravis. Comparison of myasthenic sceletal muscle antibodies with rabbit and rat antibodies produced by immunization with skeletal muscle proteins].重症肌无力的免疫病理学。重症肌无力骨骼肌抗体与用骨骼肌蛋白免疫产生的兔和大鼠抗体的比较
Res Exp Med (Berl). 1973 May 21;160(3):181-95. doi: 10.1007/BF01856782.
8
Skeletal and heart muscle antibodies in myasthenia gravis. A new immunofluorescence pattern.重症肌无力中的骨骼肌和心肌抗体。一种新的免疫荧光模式。
Biomedicine. 1973 Jun 20;19(6):261-6.
9
[Myasthenia gravis. Immunologic aspects].
Tidsskr Nor Laegeforen. 1971 Apr 20;91(11):819-21.
10
Myasthenia gravis, autoimmunity and the thymus.重症肌无力、自身免疫与胸腺。
Adv Intern Med. 1968;14:241-80.

引用本文的文献

1
[The pathogenesis of myasthenia gravis as an immunological problem].[重症肌无力作为免疫问题的发病机制]
Klin Wochenschr. 1970 Jan 1;48(1):4-13. doi: 10.1007/BF01486122.
2
Studies in myasthenia gravis. Heat stability and species specificity of active muscle antigens.重症肌无力研究。活性肌肉抗原的热稳定性和物种特异性。
Immunology. 1973 Jun;24(6):1035-40.
3
Binding of gamma-globulin fragments to muscle tissue.γ-球蛋白片段与肌肉组织的结合。

本文引用的文献

1
Changes in serum complement activity in patients with myasthenia gravis.重症肌无力患者血清补体活性的变化
Proc Soc Exp Biol Med. 1960 Oct;105:177-84. doi: 10.3181/00379727-105-26050.
2
Studies in myasthenia gravis: immunofluorescent tagging of muscle striation with antibody from serums of 256 myasthenic patients.重症肌无力研究:用256例重症肌无力患者血清中的抗体对肌肉条纹进行免疫荧光标记。
Ann N Y Acad Sci. 1965 Jun 30;124(2):730-43. doi: 10.1111/j.1749-6632.1965.tb18998.x.
3
Immunofluorescence staining patterns in skeletal muscle using serum of myasthenic patients and normal controls.
Clin Exp Immunol. 1970 Jul;7(1):23-30.
4
Antiglobulin consumption test with sera from patients with myasthenia gravis.用重症肌无力患者血清进行抗球蛋白消耗试验。
Clin Exp Immunol. 1970 Jul;7(1):11-21.
5
Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin.重症肌无力合并胸腺瘤的患者血清中存在抗肌联蛋白的IgG自身抗体。
Clin Exp Immunol. 1990 Nov;82(2):284-8. doi: 10.1111/j.1365-2249.1990.tb05440.x.
6
A shared epitope in the acetylcholine receptor-alpha subunit and fast troponin I of skeletal muscle. Is it important for myasthenia gravis?乙酰胆碱受体α亚基与骨骼肌快速肌钙蛋白I中的一个共同表位。它对重症肌无力很重要吗?
Am J Pathol. 1992 May;140(5):1215-23.
7
Absence of cellular hypersensitivity to muscle and thymic antigens in myasthenia gravis.重症肌无力患者不存在对肌肉和胸腺抗原的细胞超敏反应。
J Neurol Neurosurg Psychiatry. 1975 Nov;38(11):1039-47. doi: 10.1136/jnnp.38.11.1039.
8
Different myosins in myoid and entodermal reticular epithelial cells of the thymus. An immunocytochemical study using specific antibodies against striated and smooth muscle myosin.胸腺肌样细胞和内胚层网状上皮细胞中的不同肌球蛋白。一项使用抗横纹肌和平滑肌肌球蛋白特异性抗体的免疫细胞化学研究。
Cell Tissue Res. 1978 Feb 14;187(1):97-103. doi: 10.1007/BF00220621.
9
Light microscopic demonstration of myoid material in nuclei.
Histochemistry. 1976 Feb 26;46(3):237-43. doi: 10.1007/BF02462787.
10
Myoepithelial cells in human thymus: staining, polarization and fluorescence microscopic studies.
Histochemistry. 1975 Nov 21;45(2):163-76. doi: 10.1007/BF00495159.
使用重症肌无力患者血清和正常对照血清对骨骼肌进行免疫荧光染色模式。
Immunology. 1965 Jul;9(1):93-5.
4
Further studies on the specificity of presumed immune associations of myasthenia gravis and consideration of possible pathogenic implications.重症肌无力假定免疫关联的特异性进一步研究及对可能致病影响的思考
Ann N Y Acad Sci. 1966 Jan 26;135(1):557-79. doi: 10.1111/j.1749-6632.1966.tb45504.x.
5
Mucin secretion and striated muscle in the human thymus.人类胸腺中的粘蛋白分泌与横纹肌
Lancet. 1966 Jan 22;1(7430):183-5. doi: 10.1016/s0140-6736(66)90703-3.