二胺氧化酶反应的动力学
Kinetics of the diamine oxidase reaction.
作者信息
Bardsley W G, Crabbe M J, Shindler J S
出版信息
Biochem J. 1973 Mar;131(3):459-69. doi: 10.1042/bj1310459.
Abstract
- The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced under a wide variety of experimental conditions. 2. The effect of variations in concentrations of both substrates (amine and oxygen) and all products (aminoaldehyde, hydrogen peroxide and ammonia) on this reaction was studied and the results used to develop a formal mechanism. 3. The nature of the rate-limiting step was elucidated by studying the effects of alterations in ionic strength, dielectric constant and deuterium substitution on the velocity of the forward reaction. 4. Thermodynamic activation energy parameters were obtained at several pH values from the effects of temperature on the reaction.
摘要
- 在多种实验条件下，通过分光光度法测量由对二甲基氨基甲基苯甲醛产生的E(250)变化，跟踪对二甲基氨基甲基苄胺的氧化过程。2. 研究了两种底物（胺和氧）以及所有产物（氨基醛、过氧化氢和氨）浓度变化对该反应的影响，并将结果用于推导一个形式化的反应机理。3. 通过研究离子强度、介电常数和氘取代对正向反应速度的影响，阐明了限速步骤的性质。4. 根据温度对反应的影响，在几个pH值下获得了热力学活化能参数。
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