底物类似物对猪肾二胺氧化酶的抑制作用。
Inhibition of pig kidney diamine oxidase by substrate analogues.
作者信息
Bardsley W G, Ashford J S
出版信息
Biochem J. 1972 Jun;128(2):253-63. doi: 10.1042/bj1280253.
Abstract
- The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced. 2. This reaction was inhibited by substrate analogues such as isothiouronium, guanidino, dimethylsulphonium and trimethylammonium compounds. 3. The inhibition by both mono- and bis-onium compounds has been studied and a comprehensive theory is developed to explain both the type and degree of inhibition produced.
摘要
- 通过测量由对二甲氨基甲基苯甲醛生成所引起的E(250)变化，用分光光度法跟踪对二甲氨基甲基苄胺的氧化反应。2. 该反应受到底物类似物的抑制，如异硫脲、胍基、二甲基锍和三甲基铵化合物。3. 对单铵化合物和双铵化合物的抑制作用进行了研究，并提出了一个综合理论来解释所产生的抑制类型和程度。
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本文引用的文献
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The inhibition of histaminase by amidines.脒类对组胺酶的抑制作用。
Biochem J. 1951 Jul;49(2):250-3. doi: 10.1042/bj0490250.
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The kinetics of enzyme-catalyzed reactions with two or more substrates or products. III. Prediction of initial velocity and inhibition patterns by inspection.双底物或多底物及多产物酶催化反应的动力学。III. 通过观察预测初速度和抑制模式
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The kinetics of enzyme-catalyzed reactions with two or more substrates or products. II. Inhibition: nomenclature and theory.具有两种或更多种底物或产物的酶催化反应动力学。II. 抑制作用：命名法与理论
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The kinetics of enzyme-catalyzed reactions with two or more substrates or products. I. Nomenclature and rate equations.具有两种或更多种底物或产物的酶催化反应动力学。I. 命名法和速率方程。
Biochim Biophys Acta. 1963 Jan 8;67:104-37. doi: 10.1016/0006-3002(63)91800-6.
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Inhibition of diamine oxidase by bulbocapnine.白屈菜碱对二胺氧化酶的抑制作用。
Biochem Pharmacol. 1962 Mar;11:205-10. doi: 10.1016/0006-2952(62)90075-8.
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Evidence for a ping-pong mechanism in the diamine oxidase reaction.二胺氧化酶反应中乒乓机制的证据。
FEBS Lett. 1969 Jul;4(1):31-32. doi: 10.1016/0014-5793(69)80188-2.
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Copper reduction by substrate in diamine oxidase.二胺氧化酶中底物对铜的还原作用
FEBS Lett. 1969 Jan;2(3):182-184. doi: 10.1016/0014-5793(69)80013-x.
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