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肝病患者的血清免疫球蛋白、补体成分水平及自身抗体

Serum immunoglobulins, complement component levels and autoantibodies in liver disease.

作者信息

Thompson R A, Carter R, Stokes R P, Geddes A M, Goodall J A

出版信息

Clin Exp Immunol. 1973 Jul;14(3):335-46.

PMID:4199089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553834/
Abstract

Serum immunoglobulins, complement component levels and autoantibodies were measured in patients presenting with acute and chronic liver disease. One-hundred and seventeen patients were studied and the results of the immunological estimations were found to be of value in the differential diagnosis of liver disease when considered in conjunction with clinical and other laboratory findings. The results of the study are of interest in discussing the possible pathogenesis of liver disease.

摘要

对患有急慢性肝病的患者进行了血清免疫球蛋白、补体成分水平及自身抗体的检测。共研究了117例患者，发现免疫测定结果与临床及其他实验室检查结果相结合时，对肝病的鉴别诊断具有价值。该研究结果对于探讨肝病可能的发病机制具有重要意义。

相似文献

1
Serum immunoglobulins, complement component levels and autoantibodies in liver disease.肝病患者的血清免疫球蛋白、补体成分水平及自身抗体
Clin Exp Immunol. 1973 Jul;14(3):335-46.
2
Immunoglobulin and autoantibody response in acute and chronic liver disease.急性和慢性肝病中的免疫球蛋白及自身抗体反应
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BA and SH antigen in chronic hepatitis.慢性肝炎中的BA和SH抗原
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4
[Discriminant studies of immunoglobulins in diseases of the liver and biliary tract].[肝脏和胆道疾病中免疫球蛋白的鉴别研究]
Zh Mikrobiol Epidemiol Immunobiol. 1976(3):120-6.
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Serum immunoglobulin concentrations and autoantibody titers in diseases of the liver and biliary tree.
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[Activity of serum immunoglobulins and 1C- 1A globulins in acute virus hepatitis and chronic liver diseases].[急性病毒性肝炎和慢性肝病中血清免疫球蛋白及1C-1A球蛋白的活性]
Dtsch Z Verdau Stoffwechselkr. 1972;32(1):123-6.
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[Analysis of immunoglobulins in obstructive jaundice].[阻塞性黄疸中免疫球蛋白的分析]
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[Quantitative immunoglobulin determinations in hepatobiliary diseases. Discriminant analytical study].[肝胆疾病中免疫球蛋白的定量测定。判别分析研究]
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[Results of quantitative determination of immunoglobulins in chronic liver diseases].[慢性肝病中免疫球蛋白定量测定结果]
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Significance of serum complement levels in chronic liver disease.血清补体水平在慢性肝病中的意义。
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引用本文的文献

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Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.血清标志物可区分胆汁淤积症与其他形式的新生儿胆汁淤积。
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Pediatr Nephrol. 1993 Feb;7(1):6-10. doi: 10.1007/BF00861550.
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Clinical study of IgA antibody against hepatitis C virus core antigen in patients with type C chronic liver disease.丙型慢性肝病患者抗丙型肝炎病毒核心抗原IgA抗体的临床研究。
Dig Dis Sci. 1995 Feb;40(2):457-64. doi: 10.1007/BF02065435.
4
IgM and IgA antibodies generated against hepatitis C virus core antigen in patients with acute and chronic HCV infection.急性和慢性丙型肝炎病毒感染患者体内产生的针对丙型肝炎病毒核心抗原的IgM和IgA抗体。
Dig Dis Sci. 1994 Sep;39(9):2022-31. doi: 10.1007/BF02088141.
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Studies on secretory component in digestive disease. IV. Levels of serum secretory component in liver disease.消化系统疾病中分泌成分的研究。IV. 肝脏疾病中血清分泌成分的水平。
Gastroenterol Jpn. 1980;15(5):448-51. doi: 10.1007/BF02773907.
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Studies on secretory component in digestive disease. III. Levels of serum secretory component in digestive disease.消化系统疾病中分泌成分的研究。III. 消化系统疾病患者血清分泌成分水平
Gastroenterol Jpn. 1980;15(5):444-7. doi: 10.1007/BF02773906.
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Reassessment of levels of secretory IgA in pathological sera using a quantitative radioimmunoassay.使用定量放射免疫分析法重新评估病理血清中分泌型免疫球蛋白A的水平。
Clin Exp Immunol. 1981 Mar;43(3):633-40.
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Secretory component (SC): preferential binding to heavy (greater than 11S) IgA polymers and IgM in serum, in contrast to predominance of 11S and free SC forms in secretions.分泌成分（SC）：与血清中重链（大于11S）IgA聚合物和IgM优先结合，而在分泌物中则以11S和游离SC形式为主。
Clin Exp Immunol. 1982 Sep;49(3):717-24.
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Serum and intestinal secretory IgA in alcoholic cirrhosis of the liver.酒精性肝硬化患者血清及肠道分泌型免疫球蛋白A
Gut. 1982 Jun;23(6):475-80. doi: 10.1136/gut.23.6.475.
10
High serum levels of secretory IgA in liver disease: possible liver origin of the circulating secretory component.肝病患者血清中分泌型IgA水平升高：循环分泌成分可能源于肝脏。
Dig Dis Sci. 1982 Apr;27(4):333-40. doi: 10.1007/BF01296753.

本文引用的文献

1
SEROLOGICAL TESTS IN DIAGNOSIS OF PRIMARY BILIARY CIRRHOSIS.原发性胆汁性肝硬化诊断中的血清学检测
Lancet. 1965 Apr 17;1(7390):827-31. doi: 10.1016/s0140-6736(65)91372-3.
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Quantitation of exocrine IgA in human serum in health and disease.健康与疾病状态下人体血清中外分泌型免疫球蛋白A的定量分析。
Clin Exp Immunol. 1970 Oct;7(4):491-500.
3
Biosynthesis of the second (C2) and fourth (C4) components of complement in vitro by tissues isolated from guinea-pigs with genetically determined C4 deficiency.用遗传性C4缺陷豚鼠分离的组织在体外进行补体第二（C2）和第四（C4）成分的生物合成。
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The serum concentration of the third component of complement beta-1C-beta-1A in liver disease.肝病中补体β-1C-β-1A第三成分的血清浓度。
Gut. 1971 Jul;12(7):574-8. doi: 10.1136/gut.12.7.574.
5
The pathogenesis of arthritis associated with viral hepatitis. Complement-component studies.与病毒性肝炎相关的关节炎的发病机制。补体成分研究。
N Engl J Med. 1971 Jul 22;285(4):185-9. doi: 10.1056/NEJM197107222850401.
6
Synthesis of the first component of guinea pig complement by columnar epithelial cells of the small intestine.豚鼠补体第一成分由小肠柱状上皮细胞合成。
J Immunol. 1968 Apr;100(4):788-92.
7
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
Immunochemistry. 1965 Sep;2(3):235-54. doi: 10.1016/0019-2791(65)90004-2.
8
Human C'3: evidence for the liver as the primary site of synthesis.人补体C3：肝脏作为主要合成部位的证据。
Science. 1969 Jan 17;163(3864):286-8. doi: 10.1126/science.163.3864.286.
9
Serum immunoglobulin levels in Australia antigen positive and Australia antigen negative hepatitis.澳大利亚抗原阳性和阴性肝炎患者的血清免疫球蛋白水平
Clin Exp Immunol. 1972 Jul;11(3):381-91.
10
Complement levels in acute infectious hepatitis and serum hepatitis.急性传染性肝炎和血清性肝炎中的补体水平。
Clin Exp Immunol. 1972 May;11(1):31-5.