Donovan R, Soothill J F
Clin Exp Immunol. 1973 Jul;14(3):347-57.
Serum IgA concentrations in children undergoing tonsillectomy for recurrent sore throats were lower than those of a control population. was usually grown from children with lower IgA concentrations, near to and below 2 SD below the control mean. Their values were significantly lower than those from patients from whom β haemolytic streptococci were grown. Some of the children with low IgA had low antistreptolysin titres and little or no lymphocyte response to PHA. There was no relationship between the immunological findings and the pre-operative severity of symptoms, but there was with the incidence of infection in the post-operative year. These findings will necessitate reappraisal of surgery and prophylactic antibiotics in the two groups separately. These findings suggest that tonsils from children presenting with indistinguishable syndromes are infected with different bacteria, depending on the immunological function of the child. Since tonsillectomy is common, there appears to be clinical relevance for the range of immunological function near to or within the `normal limits'.
因复发性喉咙痛接受扁桃体切除术的儿童血清IgA浓度低于对照组人群。通常从IgA浓度较低的儿童中培养出（某种细菌），这些儿童的IgA浓度接近并低于对照组均值2个标准差。他们的值显著低于培养出β溶血性链球菌的患者的值。一些IgA水平低的儿童抗链球菌溶血素滴度低，对PHA的淋巴细胞反应很少或没有。免疫学结果与术前症状严重程度之间没有关系，但与术后一年的感染发生率有关。这些发现将需要分别重新评估两组患者的手术和预防性抗生素使用情况。这些发现表明，表现出难以区分综合征的儿童的扁桃体感染了不同的细菌，这取决于儿童的免疫功能。由于扁桃体切除术很常见，“正常范围”附近或之内的免疫功能范围似乎具有临床意义。
