Korsrud F R, Brandtzaeg P
Clin Exp Immunol. 1980 Feb;39(2):361-70.
The relative contributions of the various lymphoid tissue compartments (follicle centre, mantle zone, extrafollicular area, and reticular epithelium) of clinically normal nasopharyngeal (adenoid) and palatine tonsils of young children (mean age 5, range 2–10 years) were found to be almost identical in the two organs. In adenoid hypertrophy and recurrent palatine tonsillitis a significant relative reduction of the contributions of follicle centres and mantle zones occurred along with an increase of the extrafollicular compartment. The tonsillar Ig-producing cell systems in health and disease were studied by paired immunohistochemical staining. Only occasional IgE-producing cells were seen in normal as well as in diseased specimens. A general predominance of IgG cells followed by the IgA, IgM and IgD classes was demonstrated in both organs. In the palatine tonsils the percentage class ratios (64·4:29·6:4·3:1·7) were virtually unaltered in disease. Conversely, the class ratios were changed from 54·2:35·2:7·4:3·3 in healthy adenoids to 70·3:23·3:4·7:1·7 in hypertrophy. Intensified B-cell stimulation associated with disease was indicated as the follicle centres tended to show an increased density of Ig-producing cells—at least in the palatine tonsils—and, moreover, showed a significant shift to IgG expression. Taking the histomorphometric data into account, a decreased number of extrafollicular Ig-producing cells per tissue unit was indicated in recurrent tonsillitis. This change was most likely secondary to the disease. Conversely, the hypertrophic adenoids showed significantly increased B-cell activity in the extrafollicular compartment—a raised number of IgG-producing cells being especially marked. A difference between the two organs in the response pattern of the Ig-producing cells, especially in the reticular epithelium, might be influenced by a contribution of the secretory immune system to the surface protection of the adenoids.
研究发现，幼儿（平均年龄5岁，范围2至10岁）临床正常的鼻咽部（腺样体）和腭扁桃体的各个淋巴组织区室（滤泡中心、套区、滤泡外区域和网状上皮）的相对贡献在这两个器官中几乎相同。在腺样体肥大和复发性腭扁桃体炎中，滤泡中心和套区的贡献相对显著减少，同时滤泡外区室增加。通过配对免疫组织化学染色研究了健康和患病状态下扁桃体的Ig产生细胞系统。在正常和患病标本中仅偶尔可见产生IgE的细胞。在两个器官中均显示IgG细胞普遍占优势，其次是IgA、IgM和IgD类。在腭扁桃体中，疾病状态下各类别的百分比比例（64·4:29·6:4·3:1·7）几乎未改变。相反，健康腺样体的类别比例从54·2:35·2:7·4:3·3变为肥大状态下的70·3:23·3:4·7:1·7。由于滤泡中心倾向于显示产生Ig的细胞密度增加——至少在腭扁桃体中如此——而且显示出向IgG表达的显著转变，提示与疾病相关的B细胞刺激增强。考虑到组织形态计量学数据，复发性扁桃体炎中每个组织单位的滤泡外产生Ig的细胞数量减少。这种变化很可能是疾病的继发结果。相反，肥大的腺样体在滤泡外区室显示出显著增加的B细胞活性——产生IgG的细胞数量增加尤为明显。产生Ig的细胞反应模式在两个器官之间的差异，尤其是在网状上皮中，可能受到分泌免疫系统对腺样体表面保护作用的影响。
