Aperia A, Bergstrand A, Broberger O, Linné T, Wasserman J
Acta Paediatr Scand. 1979 Mar;68(2):173-80. doi: 10.1111/j.1651-2227.1979.tb04985.x.
Renal function was studied in three patients with post-streptococcal, four patients with IgA and one patient with non-streptococcal proliferative glomerulonephritis (GN) at the onset of the disease and two, six and 12 months later. Renal biopsies were performed at the onset of the disease and 12 months later. Standard clearance techniques were used for the functional studies. The latter were performed during hydropenia and continuous isotonic saline infusion. During hydropenia, the GFR was uniformly depressed shortly after the onset of the disease, but it normalized during the following two months. The filtration fraction was depressed in poststreptococcal GN at the onset and it normalized with the GFR. In IgA GN, the filtration fraction remained within normal limits during the entire course of the illness. The natriuretic response to isotonic saline volume expansion was low in all patients at the onset of the disease, but normalized in post-streptococcal and IgA GN during the one-year follow-up. In spite of normalized renal function, biopsy findings in IgA GN were unchanged 12 months later. An episode of macroscopic hematuria in one patient with IgA GN at the six-month investigation had no apparent effect on renal function.
对3例链球菌感染后肾小球肾炎、4例IgA肾病和1例非链球菌感染增殖性肾小球肾炎（GN）患者在疾病发作时以及之后2个月、6个月和12个月进行了肾功能研究。在疾病发作时和12个月后进行了肾活检。功能研究采用标准清除技术。后者在禁水和持续输注等渗盐水期间进行。在禁水期间，疾病发作后不久肾小球滤过率（GFR）均下降，但在接下来的两个月内恢复正常。链球菌感染后GN发作时滤过分数下降，随GFR恢复正常。在IgA肾病中，滤过分数在疾病全过程中均保持在正常范围内。所有患者在疾病发作时对等渗盐水扩容的利钠反应均较低，但在链球菌感染后和IgA肾病患者的一年随访中恢复正常。尽管肾功能恢复正常，但IgA肾病患者12个月后的活检结果未改变。1例IgA肾病患者在6个月检查时出现肉眼血尿发作，对肾功能无明显影响。
