Ek J, Magnus E M
Acta Paediatr Scand. 1979 Mar;68(2):239-43. doi: 10.1111/j.1651-2227.1979.tb04995.x.
We have studied growth, red blood cell status and folate concentrations in plasma and red cells in a group of 35 breastfed infants during the first year of life. Folic acid supplementation was not given to the mothers during pregnancy or lactation, and none of them developed megaloblastic anaemia. The growth and red blood cell status of the infants were both normal. At birth, and throughout the period of observation, the folate concentrations in plasma and red cells were significantly higher than in the adult reference material. A positive correlation between plasma and red cell folate was demonstrated. During the latter part of pregnancy and lactation the foetuses and infants seem to be protected against folate deficiency. We regard the folate status of normal breastfed infants as optimal. The optimal supply of the vitamin in artificial nutrition should be the amount of folate necessary to maintain plasma and red cell folate concentrations similar to those found in breastfed infants.
我们研究了一组35名母乳喂养婴儿在出生后第一年的生长情况、红细胞状态以及血浆和红细胞中的叶酸浓度。在孕期和哺乳期，母亲均未补充叶酸，且她们均未发生巨幼细胞贫血。婴儿的生长和红细胞状态均正常。出生时及整个观察期内，血浆和红细胞中的叶酸浓度均显著高于成人参考标准。血浆和红细胞叶酸之间呈正相关。在妊娠后期和哺乳期，胎儿和婴儿似乎受到了保护，未出现叶酸缺乏。我们认为正常母乳喂养婴儿的叶酸状态是最佳的。人工营养中维生素的最佳供应量应为维持血浆和红细胞叶酸浓度与母乳喂养婴儿相似所需的叶酸量。
