Foged N, Lillquist K, Rolschau J, Blaabjerg O
Department of Paediatrics, Odense University Hospital, Denmark.
Eur J Pediatr. 1989 Oct;149(1):65-7. doi: 10.1007/BF02024339.
The effect of 250 micrograms folic acid (FA)/day or placebo given to 21 small-for-gestational-age infants born at term was studied during the first 3 months of life. The design of the study was double blind with random allocation. No randomization was performed in respect of breast-feeding or formula-feeding with a folate content of 60-70 micrograms/l. No significant differences were observed in haemoglobin concentration, haematocrit, weight and length between FA-supplemented and non-supplemented infants. A negative correlation was demonstrated between gestational age and erythrocyte folate (E-folate) concentration at 1 week. E-folate content was higher when no supplement was given in breast-fed than in formula-fed infants.
