一种新型抗肿瘤抗代谢物，（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（NSC-163501）：抗菌逆转研究及体内抗L1210小鼠白血病的初步评估 - Suppr

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A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo.

作者信息

Hanka L J, Martin D G, Neil G L

出版信息

Cancer Chemother Rep. 1973 Apr;57(2):141-8.

PMID:4200486

Abstract

摘要

相似文献

A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo.一种新型抗肿瘤抗代谢物，（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（NSC-163501）：抗菌逆转研究及体内抗L1210小鼠白血病的初步评估

Cancer Chemother Rep. 1973 Apr;57(2):141-8.

A new antitumor agent, (alphas, 4s, 5r)-alpha-amino-3-chloro-4-hydroxy-4,5-dihydro-5-isoxazoleacetic acid (NSC-176324): preliminary evaluation against L 1210 mouse leukemia in vivo.一种新型抗肿瘤药物，（αS，4S，5R）-α-氨基-3-氯-4-羟基-4,5-二氢-5-异恶唑乙酸（NSC-176324）：对L 1210小鼠白血病的体内初步评价

Cancer Chemother Rep. 1974 Nov-Dec;58(6):935-7.

Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).发酵衍生抗肿瘤剂（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125）的生化和药理作用

Cancer Res. 1979 Mar;39(3):852-6.

Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.不动杆菌L-谷氨酰胺酶-L-天冬酰胺酶对L-谷氨酰胺拮抗剂L-(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸的增强作用。

Cancer Treat Rep. 1979 Jun;63(6):1109-14.

Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).发酵来源的抗肿瘤药物（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125）的生化药理学研究

Adv Enzyme Regul. 1978;17:375-98. doi: 10.1016/0065-2571(79)90023-2.

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine.L-[αS, 5S]-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（NSC-163501）：一种具有L-谷氨酰胺拮抗剂特性的新型氨基酸抗生素。

Cancer Chemother Rep. 1975 May-Jun;59(3):481-91.

Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).P388白血病一种变体对L-(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（阿西维辛）的耐药机制。

Cancer Res. 1985 Jan;45(1):207-12.

Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.使用抗肿瘤抗生素AT-125对小鼠肿瘤和人肿瘤异种移植模型进行治疗。

Cancer Treat Rep. 1979 Mar;63(3):473-6.

Experimental antitumor activity and toxicity of a new chemotherapeutic agent, BBM 928A.新型化疗药物BBM 928A的实验性抗肿瘤活性与毒性

Cancer Res. 1983 Apr;43(4):1504-10.

Activity of anthracyclines against an adriamycin (NSC-123127)-resistant subline of P388 leukemia with special emphasis on cinerubin A (NSC-18334).蒽环类药物对阿霉素（NSC - 123127）耐药的P388白血病亚系的活性，特别着重于烬灰红菌素A（NSC - 18334）。

Cancer Treat Rep. 1976 Jan;60(1):99-102.

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J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.

Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k.阿西维辛在癌细胞中的靶点发现阐明了其生长抑制机制† 可获取电子补充信息（ESI）：合成、克隆、蛋白质表达、纯化及生化分析。见DOI: 10.1039/c4sc02339k。

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Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with Escherichia coli K-12.联合功能基因组-生化方法研究中间代谢：谷氨酰胺酰胺转移酶抑制剂阿西维辛与大肠杆菌K-12的相互作用

J Bacteriol. 2001 Jun;183(11):3353-64. doi: 10.1128/JB.183.11.3353-3364.2001.

Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.γ-谷氨酰氨基酸对γ-谷氨酰转肽酶的抑制作用及谷胱甘肽尿的诱导作用。

Proc Natl Acad Sci U S A. 1986 Jul;83(14):5029-32. doi: 10.1073/pnas.83.14.5029.

Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.（αS，5S）-2-氨基-3-氯-4,5-二氢-5-异恶唑乙酸与5-氟尿嘧啶在P388白血病中协同作用的生化机制。

Cancer Chemother Pharmacol. 1985;15(1):44-8. doi: 10.1007/BF00257293.

Intracerebral chemotherapy in the 9L rat brain tumor model.

J Neurooncol. 1992 Nov;14(3):191-200. doi: 10.1007/BF00172594.

Improved methods for production, isolation, and assay of two new chlorisoxazoline amino acid antitumor antimetabolites: U-42, 126 and U43, 795.两种新型氯异恶唑啉氨基酸抗肿瘤抗代谢物U-42,126和U43,795的生产、分离及测定的改进方法。

Antimicrob Agents Chemother. 1975 Jun;7(6):807-10. doi: 10.1128/AAC.7.6.807.

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