发酵衍生抗肿瘤剂（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125）的生化和药理作用 - Suppr

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Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).

作者信息

Neil G L, Berger A E, McPartland R P, Grindey G B, Bloch A

出版信息

Cancer Res. 1979 Mar;39(3):852-6.

PMID:427775

Abstract

摘要

相似文献

Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).发酵衍生抗肿瘤剂（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125）的生化和药理作用

Cancer Res. 1979 Mar;39(3):852-6.

Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).发酵来源的抗肿瘤药物（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125）的生化药理学研究

Adv Enzyme Regul. 1978;17:375-98. doi: 10.1016/0065-2571(79)90023-2.

Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.不动杆菌L-谷氨酰胺酶-L-天冬酰胺酶对L-谷氨酰胺拮抗剂L-(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸的增强作用。

Cancer Treat Rep. 1979 Jun;63(6):1109-14.

The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（AT-125；NSC-163501）对人胰腺癌细胞γ-谷氨酰转肽酶的抑制作用

Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):175-82.

A new antitumor agent, (alphas, 4s, 5r)-alpha-amino-3-chloro-4-hydroxy-4,5-dihydro-5-isoxazoleacetic acid (NSC-176324): preliminary evaluation against L 1210 mouse leukemia in vivo.一种新型抗肿瘤药物，（αS，4S，5R）-α-氨基-3-氯-4-羟基-4,5-二氢-5-异恶唑乙酸（NSC-176324）：对L 1210小鼠白血病的体内初步评价

Cancer Chemother Rep. 1974 Nov-Dec;58(6):935-7.

Acivicin. An antitumor antibiotic.阿西维辛。一种抗肿瘤抗生素。

Cancer Clin Trials. 1981 Fall;4(3):327-30.

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine.L-[αS, 5S]-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（NSC-163501）：一种具有L-谷氨酰胺拮抗剂特性的新型氨基酸抗生素。

Cancer Chemother Rep. 1975 May-Jun;59(3):481-91.

Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).P388白血病一种变体对L-(αS,5S)-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（阿西维辛）的耐药机制。

Cancer Res. 1985 Jan;45(1):207-12.

A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo.一种新型抗肿瘤抗代谢物，（αS，5S）-α-氨基-3-氯-4,5-二氢-5-异恶唑乙酸（NSC-163501）：抗菌逆转研究及体内抗L1210小鼠白血病的初步评估

Cancer Chemother Rep. 1973 Apr;57(2):141-8.

Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.使用抗肿瘤抗生素AT-125对小鼠肿瘤和人肿瘤异种移植模型进行治疗。

Cancer Treat Rep. 1979 Mar;63(3):473-6.

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Alterations in cellular metabolism triggered by or inactivation cause imbalanced dNTP pools and increased mutagenesis.或失活引发的细胞代谢改变会导致 dNTP 池失衡和诱变增加。

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4442-E4451. doi: 10.1073/pnas.1618714114. Epub 2017 Apr 17.

Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition†Electronic supplementary information (ESI) available: Synthesis, cloning, protein expression, purification and biochemical assays. See DOI: 10.1039/c4sc02339k.阿西维辛在癌细胞中的靶点发现阐明了其生长抑制机制† 可获取电子补充信息（ESI）：合成、克隆、蛋白质表达、纯化及生化分析。见DOI: 10.1039/c4sc02339k。

Chem Sci. 2014 Dec 1;6(1):237-245. doi: 10.1039/c4sc02339k. Epub 2014 Sep 26.

Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness.布氏锥虫CTP合成酶：治疗非洲昏睡病的一个靶点。

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6412-6. doi: 10.1073/pnas.111139498. Epub 2001 May 15.

Protease-activated "prodrugs" for cancer chemotherapy.用于癌症化疗的蛋白酶激活“前药”。

Proc Natl Acad Sci U S A. 1980 Apr;77(4):2224-8. doi: 10.1073/pnas.77.4.2224.

Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.γ-谷氨酰氨基酸对γ-谷氨酰转肽酶的抑制作用及谷胱甘肽尿的诱导作用。

Proc Natl Acad Sci U S A. 1986 Jul;83(14):5029-32. doi: 10.1073/pnas.83.14.5029.

Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.（αS，5S）-2-氨基-3-氯-4,5-二氢-5-异恶唑乙酸与5-氟尿嘧啶在P388白血病中协同作用的生化机制。

Cancer Chemother Pharmacol. 1985;15(1):44-8. doi: 10.1007/BF00257293.

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