γ-谷氨酰氨基酸对γ-谷氨酰转肽酶的抑制作用及谷胱甘肽尿的诱导作用。
Inhibition of gamma-glutamyl transpeptidase and induction of glutathionuria by gamma-glutamyl amino acids.
作者信息
Anderson M E, Meister A
出版信息
Proc Natl Acad Sci U S A. 1986 Jul;83(14):5029-32. doi: 10.1073/pnas.83.14.5029.
Abstract
Treatment of mice with various gamma-glutamyl amino acids leads to marked urinary excretion of glutathione and other gamma-glutamyl compounds. There is good correlation between the affinity of gamma-glutamyl transpeptidase for various gamma-glutamyl amino acids and the extent of glutathionuria. The findings indicate that the administered gamma-glutamyl compounds effectively compete with glutathione (exported from kidney cells and present in the glomerular filtrate) for the enzyme. The administration of certain gamma-glutamyl amino acids appears to be a specific and nontoxic procedure for in vivo inhibition of gamma-glutamyl transpeptidase that may be useful in experimental work on glutathione metabolism and function and also for treatment of certain toxicities and for modulation of the metabolism of endogenous glutathione conjugates.
摘要
用各种γ-谷氨酰氨基酸处理小鼠会导致谷胱甘肽和其他γ-谷氨酰化合物在尿液中大量排泄。γ-谷氨酰转肽酶对各种γ-谷氨酰氨基酸的亲和力与谷胱甘肽尿的程度之间存在良好的相关性。这些发现表明，所给予的γ-谷氨酰化合物与（从肾细胞输出并存在于肾小球滤液中的）谷胱甘肽有效竞争该酶。给予某些γ-谷氨酰氨基酸似乎是一种体内抑制γ-谷氨酰转肽酶的特异性且无毒的方法，这可能有助于谷胱甘肽代谢和功能的实验研究，也可用于治疗某些毒性以及调节内源性谷胱甘肽结合物的代谢。
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