热不稳定因子对人中和痘苗病毒的影响。
Effect of heat-labile factors on the neutralization of vaccinia virus by human.
作者信息
Takabayashi K, McIntosh K
出版信息
Infect Immun. 1973 Oct;8(4):582-9. doi: 10.1128/iai.8.4.582-589.1973.
Abstract
The effect of unheated guinea pig and human prevaccination serum on the neutralization of vaccinia virus was studied. Enhancement of neutralization was found in all sera containing antibody and was more marked (20- to 150-fold) in sera obtained in the first weeks after primary vaccination than in sera from immune adults or cord sera (4- to 25-fold). The enhancing factor was thought to be complement because it was destroyed by heating and ethylenediaminetetraacetic acid treatment. The fresh serum-enhanced neutralization test represents a highly sensitive and specific test which can be applied to measure low levels of vaccinia antibody not detectable by other means.
摘要
研究了未加热的豚鼠和人接种疫苗前血清对痘苗病毒中和作用的影响。在所有含有抗体的血清中均发现中和作用增强，且在初次接种后的头几周获得的血清中更为明显（增强20至150倍），而在免疫成人的血清或脐带血清中则为4至25倍。增强因子被认为是补体，因为它会被加热和乙二胺四乙酸处理破坏。新鲜血清增强中和试验是一种高度敏感和特异的试验，可用于检测其他方法无法检测到的低水平痘苗抗体。
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